The Role of Nigrostriatal and Mesolimbic Dopaminergic Brain Systems in the Control of Voluntary Movements and Postural Adjustment in Dogs

  • K. B. Shapovalova
  • A. F. Yakimovsky

Summary

Microinjections of 3 g dopamine (DA) into the caudate nucleus head (HNC) and the nucleus accumbens (NAC) produced unidirectional effects on the motor components of avoidance instrumental reaction (IR) and posture adjustment in two groups of dogs (intact dogs and dogs with varying degrees of caudate pathology). However, each of these dopaminergic systems can mainly regulate certain components of the IR motor program, i.e. nigrostriatal system — the initiation of both the conditioned postural adjustment and the voluntary movement and mesolimbic system — the IR amplitude and stability of performance. The effects of the ipsi- and contralateral DA microinjections into HNC were, in principle, similar. The same was true of the microinjections into left and right NAC. The influence of bilateral microinjections into HNC and into NAC was stronger than that of unilateral ones. The greatest effects was obtained after combined “four-cannulae” microinjection of DA bilaterally into both structures in the dog with an akinetic form of caudate pathology. DA microinjections into the HNC of “parkinsonian” animals were followed by an improvement in all IR components and, consequently by an increase in the percentage of correct IR in the experiment. On the other hand, the normal animals with the absolutely correct IR and 100% score on the task solution apparently had a well balanced level of neostriatal mediatory system interaction. Therefore, DA microinjections into the HNC and NAC of these animals, which change this balance, disrupt the instrumental behaviour by increasing the number of interstimulus limb raising and phasic movements, overlapping the tonic instrumental reaction.

Keywords

Voluntary Movement Conditioning Signal Postural Adjustment Nigrostriatal System Instrumental Behaviour 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Albertin, S.W., 1985, Participation of the caudate nucleus DA-reactive system in regulation of instrumental conditioning of different degrees of complexity, Fiziol. Zh. im. IM. Sechenova, 71: 87.Google Scholar
  2. Beninger, B.J., 1983, The role of dopamine in locomotor activity and learning, Brain Res. Rev., 6: 173.CrossRefGoogle Scholar
  3. Brook, C., and Iversen, S.D., 1975, Changed eating and locomotor behaviour in the rat after 6-OHDA lesions to the Substantia Nigra, Neuropharmacology. 14: 95.PubMedCrossRefGoogle Scholar
  4. Bunney, B.S., Grace, A.A., and Hommer, D.W., 1980, Changing concept of nigral dopamine system functions within the basal ganglia: relevance to extrapyramidal disorders, J. Neurol. Transmit. Suppl., 16: 17.Google Scholar
  5. Chevalier, G., Thierry, A., Shibazaki, T., and Feger, J., 1981, Evidence for a GABA-ergic inhibitory nigrotectal pathway, Neurosci. Lett., 21: 6.CrossRefGoogle Scholar
  6. De Long, M.R., and Georgopoulos, A., 1981, Motor functions of the basal ganglia, in: “Handbook of Physiology”, sect.I. The Nervous System, vol. II, part 2:1017–1061.Google Scholar
  7. Dray, A.I., 1979, The striatum and substantia nigra: a commentary on their relationship, Neurosci.. 4: 1407.CrossRefGoogle Scholar
  8. Fielding, S., and Lal, H., 1978, Behavioral actions of neuroleptics, in: “Handbook of Psychopharmacology”, (L. Iversen, S. Iversen, S. Snyder, eds), pp. 91–120, Plenum Press: New-York.CrossRefGoogle Scholar
  9. Garcia-Rill, F., 1986, The Basal Ganglia and the locomotor regions, Brain Res. Rev., 11:47.CrossRefGoogle Scholar
  10. Groves, Ph. M., 1983, A theory of the functional organization of the Neostriatum and the Neostriatal control of voluntary movement, Brain Res., 5: 109.CrossRefGoogle Scholar
  11. Heimer, L., and Van Hoesen, G., 1979, Ventral striatum, in: “The Neostriatum”, (I. Divac and G. Oberg, eds), pp. 147–160, Pergamon Press: Oxford, New-York.Google Scholar
  12. Hornykiewicz, O., 1979, Brain Dopamine in Parkinson’s disease and other neurological disturbances, in: “The Neurobiology of Dopamine”, (A.S. Horn, J. Korf and B.H.C. Westernik, eds), pp. 633–654, Acad. Press, London.Google Scholar
  13. Iversen, S.D., 1977, Brain Dopamine systems and behavior, in.: “Handbook of Psychopharmacology”, (L. Iversen, S. Iversen and S. Snyder, eds), vol. 8, pp. 333–384, Plenum Press, New York.CrossRefGoogle Scholar
  14. Johnels, B., and Steg, G., 1980, The corpus striatum and the regulation of posture and locomotion, Neurosci. Lett., 19, Suppl., 5: 339.Google Scholar
  15. Kitai, S.T., 1981, Electrophysiology of the Corpus Striatum and brain stem integrating systems, in: “Handbook of Physiology”, (J. Broomhart and V. Mouncastle, eds), Sect. I, The Nervous System, v.II, part 2, pp. 997–1016, Bethesda.Google Scholar
  16. Koob, G., Simon, H., Herman, J., and Le Moal, M., 1984, Neuroleptic-like destruction of the conditioned avoidance response requires destruction of both the mesolimbic and nigrostriatal systems. Brain Res., 303: 319.PubMedCrossRefGoogle Scholar
  17. Lidsky, T., Manetto, C. and Schneider, S., 1985, A consideration of sensory factors involved in motor functions of the Basal Ganglia, Brain Res. Rev., 9: 133.CrossRefGoogle Scholar
  18. Lim, R., Liu, Ch., and Moffit, R., 1960, “A stereotaxic atlas of the dog’s brain”, Springerfield, Illinois, USAGoogle Scholar
  19. Mogenson, G., Johnes, D;, and Yim, Ch., 1980, From motivation to action functional interface between the limbic system and the motor system, Progr. in Neurobiol. 14: 69.CrossRefGoogle Scholar
  20. Mogenson, G., and Nielsen, M., 1984, Neuropharmacological evidence to suggest that the Nucleus Accumbens and Subpallidal region contribute to exploratory locomotion, Behav. and Neural. Bul., 42:52.CrossRefGoogle Scholar
  21. Mogenson, G., Swanson, L., and Wu, M., 1983, Neural projections from Nucleus Accumbens to Globus Pallidus, Substantia Innominata and lateral preoptic-lateral hypothalamic area: an anatomical and electrophysiological investigation in the rat, Neurosci., 3: 189.Google Scholar
  22. Nieoullon, A., Kerkerian, L., and Dusticier, N., 1983, Presynaptic controls in the Neostriatum: reciprocal interactions between the nigrostriatal dopaminergic neurons and the cortico-striatal glutaminergic pathway, in: “Neural coding of motor performance”, (J. Massion, ed.), pp. 54–65, Springer-Verlag: New York, Berlin, Heidelberg.CrossRefGoogle Scholar
  23. Pasik, P., Pasik, T., and Difiglia, M., 1979, The internal organization of Neostriatum in mammals, in: “The Neostriatum”, (I. Divac and G. Oberg, eds), pp. 5–36, Pergamon Press: Oxford, New-York.Google Scholar
  24. Pijnenburg, A., Honig, W., and Van Rossum, J., 1975, Inhibition of D-amphetamine induced locomotor activity by injection of haloperidol into Nucleus Accumbens of the rat, Psvchopharmacol. 41: 87.CrossRefGoogle Scholar
  25. Ranje, C., and Ungerstedt, U., 1977, High correlations between number of dopamine cells, dopamine levels and motor performance, Brain Res., 134: 83.PubMedCrossRefGoogle Scholar
  26. Shapovalova, K.B., 1984, Conditioned postural adjustment in dogs during systemic administrations of agonists and blocators of the dopaminergic brain system, Zh. Wvssh. Nervn. Deyat. im. I.P. Pavlova (In Russian), 34: 1057.Google Scholar
  27. Shapovalova, K.B., 1985, Possible neurophysiological and neurochemical mechanisms of striatum involvement in the regulation of the voluntary movement, Fiziol. Zh. im. I.M. Sechenova (In Russian), 71: 537.Google Scholar
  28. Shapovalova, K.B., Yakunin, I.V., and Boyko, M.I., 1984, Participation of dogs caudate nucleus head in the mechanisms of conditioned posture reorganization, Zh. Vvssh. Nervn. Devat. im. LP. Pavlova (In Russian), 34: 669.Google Scholar
  29. Steg, G., and Johnels, B., 1979, Motor functions of the Striatum, in: “Neostriatum”, (I. Divac and G. Oberg, eds), pp. 231–239, Pergamon Press: Oxford, New-York.Google Scholar
  30. Suvorov, N.F., and Yakimovski, A.F., 1982, The role of enkephalin-reactive system of the caudate nucleus in the performance of an alimentary conditioned reflex in dogs, Zh. Vvssh. Nervn. Devat. im. LP. Pavlova (In Russian), 32: 840.Google Scholar
  31. Ungerstedt, U., 1971, Stereotaxic mapping of the monoamine pathways in the rat brain, Acta Physiol., scand. suppl. 367, 82: 36.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • K. B. Shapovalova
    • 1
  • A. F. Yakimovsky
    • 1
  1. 1.Pavlov Institute of SciencesLeningradUSSR

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