Histochemical Evidence of Dipeptidylpeptidase IV Activity in the Schwann Cells Surrounding Unmyelinated Portions of Axons

  • Petr Dubový


Dipeptidylpeptidase IV (DPP IV) is a serine exopeptidase which removes X-Pro sequences from the N-terminal of natural peptides or artificial substrates. Its biological role in peripheral nerve structures is still obscure. However, the ability of DPP IV to degrade substance P (SP) is attractive for the explanation of the function of this enzyme in peripheral nerve structures of the skin.


Nerve Fiber Schwann Cell Artificial Substrate Natural Peptide Glabrous Skin 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Petr Dubový
    • 1
  1. 1.Department of Anatomy, Medical FacultyPurkyně UniversityBrnoCzechoslovakia

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