Histochemical Evidence of Dipeptidylpeptidase IV Activity in the Schwann Cells Surrounding Unmyelinated Portions of Axons
Dipeptidylpeptidase IV (DPP IV) is a serine exopeptidase which removes X-Pro sequences from the N-terminal of natural peptides or artificial substrates. Its biological role in peripheral nerve structures is still obscure. However, the ability of DPP IV to degrade substance P (SP) is attractive for the explanation of the function of this enzyme in peripheral nerve structures of the skin.
KeywordsNerve Fiber Schwann Cell Artificial Substrate Natural Peptide Glabrous Skin
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