Immunohistochemical Demonstration of Connective Tissue Macromolecules at the Equator of Chick Muscle Spindles

  • Alfred Maier
  • Richard Mayne


Past structural studies on muscle spindles have in large part focused on identifying intrafusal fiber types, and on characterizing sensory and motor innervations. Connective tissue components of the receptor have received considerably less attention. Cooper and Gladden (1974) have explored the functional relationship between intrafusal fibers and the elastic and reticulin fibrils which surround them, and knowledge about the structure and function of inner and outer capsules has come from the work of Shanta et al. (1968), Kennedy and Yoon (1979), Ovalle (1976) and Hikida (1985). However, the molecular basis of the connective tissue matrix occuring in spindles has yet to be demonstrated. We undertook the current immunohistochemical study to remove some of this uncertainty by evaluating the distribution of nine connective tissue macromolecules in the external lamina of intrafusal fibers and in the outer capsule at the equator of chick muscle spindles.


Collagen Type Chondroitin Sulfate Muscle Spindle Collagen Type Versus Connective Tissue Matrix 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Alfred Maier
    • 1
  • Richard Mayne
    • 1
  1. 1.Department of Cell Biology and AnatomyUniversity of Alabama at BirminghamBirminghamUSA

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