Hyperinnervation of Rat Pacinian Corpuscles in a Toxic Distal Axonopathy

  • I. Jirmanová

Abstract

During nerve regeneration following surgical injury, axonal sprouts are formed by regenerating axons at the site of nerve lesion and in the periphery. As a consequence, peripheral target tissues may become hyperinnervated (McArdle, 1975; Rotshenker and McMahan, 1976; Mira, 1981; Gorio et al., 1983; Zelená, 1984). Nerve regeneration subsequent to degeneration also occurs in individuals affected by various types of toxic axonopathies both after recovery from the intoxication and during continuing intoxication. In our experiments, we examined whether in neuropathic animals peripheral target tissues will also become reinnervated and if so, whether their innervation pattern will be altered. For morphological study, Pacinian corpuscles appeared to be the most suitable model since each of these rapidly adapting mechanoreceptors, which consists of an inner core and a capsule, is normally innervated by only one myelinated axon and one axon terminal.

Keywords

Inner Core Nerve Regeneration Axon Terminal Nerve Lesion Myelinated Axon 
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References

  1. Gorio, A., Carmignoto, G., Finesso, M., Polato, P., and Nunzi, M.G., 1983, Muscle reinnervation — II. Sprouting, synapse formation and repression, Neurosci., 8, 403–416.CrossRefGoogle Scholar
  2. Jirmanová, I., 1987, Pacinian corpuscles in rats with carbon-disulphide neuropathy, Acta Neuropathol., 72, 341–348.PubMedCrossRefGoogle Scholar
  3. Jirmanová, I., and Lukáš, E., 1984, Ultrastructure of carbon disulphide neuropathy, Acta Neuropathol., 63, 255–263.PubMedCrossRefGoogle Scholar
  4. Mira, J.C., 1981, Degeneration and regeneration of peripheral nerves: ultrastructural and electrophysiological observarions, quantitative aspects and muscle changes during reinnervation, J. Microsurg., 3, 102–120.Google Scholar
  5. McArdle, J.J., 1975, Complex end-plate potentials at the regenerating neuromuscular junction of the rat, Exp. Neurol., 49, 629–638.PubMedCrossRefGoogle Scholar
  6. Rotshenker, S., and McMahan, U.J., 1976, Altered patterns of innervation in frog muscle after denervation, J. Neurocytol., 5, 719–730.PubMedCrossRefGoogle Scholar
  7. Zelená, J., 1984, Multiple axon terminals in reinnervated Pacinian corpuscles of adult rat, J. Neurocytol., 13, 665–684.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • I. Jirmanová
    • 1
  1. 1.Institute of PhysiologyCzechoslovak Academy of SciencesPrague 4Czechoslovakia

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