Hyperinnervation of Rat Pacinian Corpuscles in a Toxic Distal Axonopathy
During nerve regeneration following surgical injury, axonal sprouts are formed by regenerating axons at the site of nerve lesion and in the periphery. As a consequence, peripheral target tissues may become hyperinnervated (McArdle, 1975; Rotshenker and McMahan, 1976; Mira, 1981; Gorio et al., 1983; Zelená, 1984). Nerve regeneration subsequent to degeneration also occurs in individuals affected by various types of toxic axonopathies both after recovery from the intoxication and during continuing intoxication. In our experiments, we examined whether in neuropathic animals peripheral target tissues will also become reinnervated and if so, whether their innervation pattern will be altered. For morphological study, Pacinian corpuscles appeared to be the most suitable model since each of these rapidly adapting mechanoreceptors, which consists of an inner core and a capsule, is normally innervated by only one myelinated axon and one axon terminal.
KeywordsInner Core Nerve Regeneration Axon Terminal Nerve Lesion Myelinated Axon
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