Taste Bud Development in Rat Vallate and Foliate Papillae

  • Bruce Oakley


Numerous studies have evaluated the neurotrophic capacity of axons to support adult mammalian taste buds. The present evidence indicates that degenerated taste buds are only regenerated by chemosensory axons and only re-formed or maintained in gustatory epithelium (reviewed in Oakley, 1985). The neurotrophic maintenance of taste buds is mediated by axonal transport (Sloan et al., 1983). The molecular mechanisms of neurotrophic support remain to be elucidated. The present paper provides an overview of a series of six recent studies from our laboratory on the development of taste buds of the vallate and foliate papillae on the posterior portion of the rat tongue. Our analyses emphasized the postnatal role that taste axons might play in the development of taste buds. The development of rat lingual taste buds is largely a postnatal process. Among mammalian mechanoreceptors with secondary sensory tissue, both muscle spindles (Zelená, 1957) and Pacinian corpuscles (Zelená, 1980) are neurally induced in development, but will survive without neurotrophic support in adults.


Sensitive Period Neural Induction Pacinian Corpuscle Taste Receptor Cell Neurotrophic Support 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hosley, M. A. and Oakley, B., 1987, Postnatal development of the vallate papilla and taste buds in rats, Anat Rec., 218:216–222.PubMedCrossRefGoogle Scholar
  2. 2.
    Hosley, M. A., Hughes, S. E., and Oakley, B., 1987a, Neural induction of taste buds, J. Comp. Neurol., 260:224–232.PubMedCrossRefGoogle Scholar
  3. 3.
    Hosley, M. A., Hughes, S. E., Morton, L. L, and Oakley, B., 1987b, A sensitive period for the neural induction of taste buds, J. Neurosci., 7:2075–2080.PubMedGoogle Scholar
  4. 4.
    Oakley, B., 1985, Trophic competence in mammalian gustation, in: “Taste, Olfaction and the Central Nervous System,” D. Pfaff, ed., Rockefeller Univ. Press, New York., pp 92–103.Google Scholar
  5. 5.
    Sloan, H. E., Hughes, S. E., and Oakley, B., 1983, Chronic impairment of axonal transport eliminates taste responses and taste buds, J. Neurosci., 3:117–123.PubMedGoogle Scholar
  6. 6.
    Zelená, J., 1957, The morphogenetic influence of innervation on the ontogenetic development of muscle spindles, J. Embryol. Exp. Morph., 5:283–292.Google Scholar
  7. 7.
    Zelená, J., 1980, Rapid degeneration of developing rat Pacinian corpuscles after denervation. Brain Res., 187:97–111.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Bruce Oakley
    • 1
  1. 1.Department of Biology, Neuroscience Laboratory BuildingUniversity of MichiganAnn ArborUSA

Personalised recommendations