Loss of Sensory and Motor Neurons After Nerve Injury in Young and Adult Rats

  • Henning Schmalbruch


The concept of Wallerian degeneration implies that the distal part of a cut axon is lost whereas the neuron survives. There are, however, exceptions from this rule, and in particular immature neurons may die after axotomy (Gudden, 1870; Lieberman, 1974). Hence, functional deficits after nerve repair may not only be due to aberrant reinnervation but also to neuron death. Axotomy-induced neuron death has also attracted interest because it relates to the neuronotrophic action of the target.


Dorsal Root Ganglion Sciatic Nerve Sensory Neuron Ventral Root Motor Axon 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Henning Schmalbruch
    • 1
  1. 1.Institute of NeurophysiologyUniversity of Copenhagen, Panum InstituteKøbenhavn NDenmark

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