Reinnervation of Grafted Pacinian Corpuscles by Dorsal Root and Dorsal Column Axons

  • I. Jirmanová
  • J. Zelená


Transplantation of various parts of the developing central nervous system (CNS) into the brain has proved to be a valuable tool for studying neuronal differentiation, connectivity and plasticity (Björklund and Stenevi, 1985; Raisman et al., 1987). In our experiments, we have used nonneuronal grafts from the periphery for testing the plasticity of dorsal root ganglion neurons. These pseudounipolar neurons are polarized: only a single process, crus commune, originates from the neuron, but it divides not far from the perikaryon into a peripheral and a central process. Both processes have the ultrastructure of axons, but differ in their polarity and form fundamentally different terminals. All central processes, i.e. dorsal root axons, terminate in the spinal cord in transmitter-releasing endings which contain a large number of synaptic vesicles, whereas peripheral axon terminals are designed to receive various kinds of stimuli either indirectly, through specialized receptor cells, or directly as transducing sensory endings which may be either free or connected with different types of corpuscular receptors; most of the peripheral sensory terminals are filled with mitochondria and contain vesicles only at their margins or extensions. We have attempted to answer the question whether the dorsal root ganglion neurons would respond to a change of the target tissue and alter the ultrastructure of their “central” endings, if their processes were connected to peripheral sensory corpuscles instead of to the spinal cord. To explore this possibility, we connected a graft of peripheral mechanoreceptors — Pacinian corpuscles — with either dorsal root axons or dorsal column axons and studied the process of axonal regeneration, the reinnervation of the grafted corpuscles and the ultrastructure of the regenerated endings.


Dorsal Root Synaptic Vesicle Dorsal Root Ganglion Neuron Inner Core Dorsal Column 
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  1. Aguayo, A.J., 1985, Axonal regeneration from injured neurons in the adult mammalian central nervous system, in: “Synaptic Plasticity”, C.W. Cotman, ed., The Guilford Press, New York, London, pp. 457–484.Google Scholar
  2. Björklund, A., and Stenevi, U., 1985, Neural Grafting in the Mammalian CNS, Fernström Foundation Series Vol. 5, Elsevier, Amsterdam, New York, Oxford.Google Scholar
  3. Raisman, G., Morris, R.J., and Zhou, C.-F., 1987, Specificity in the reinnervation of adult hippocampus by embryonic hippocampal transplants, in: “Neural Regeneration”, F.J. Seil, E. Herbert, and B.M. Carlson, eds., Progress in Brain Research Vol. 71, Elsevier, Amsterdam, pp. 325–333.CrossRefGoogle Scholar
  4. Spencer, P.S., and Schaumburg, H.H., 1973, An ultrastructural study of the inner core of Pacinian corpuscle, J. Neurocytol., 2, 217–235.PubMedCrossRefGoogle Scholar
  5. Zelená, J., 1981, Multiple innervation of rat Pacinian corpuscles regenerated after neonatal axotomy, Neuroscience, 6, 1675–1686.PubMedCrossRefGoogle Scholar
  6. Zelená, J., 1984, Multiple axon terminals in reinnervated Pacinian corpuscles of adult rat, J. Neurocytol., 13, 665–684.PubMedCrossRefGoogle Scholar
  7. Zelená, J., and Jirmanová, I., 1986, Transplantation of Pacinian corpuscles into the central nervous system, Verh. Anat. Ges., 80, 849–850.Google Scholar
  8. Zelená, J., and 3irmanová, I., 1987, Grafts of Pacinian corpuscles reinnervated by dorsal root axons, Brain Res., in press.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • I. Jirmanová
    • 1
  • J. Zelená
    • 1
  1. 1.Institute of PhysiologyCzechoslovak Academy of SciencesPragueCzechoslovakia

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