Postnatal Development and Aging of Muscle Spindles in the Mouse Masseter Muscle and Effects of a Fine-Grained Diet on Them

  • Norihiko Maeda
  • Koichi Osawa
  • Tamuro Masuda
  • Tsuyoshi Kawasaki
  • Masayoshi Kumegawa


Neuromuscular spindles of skeletal muscles of vertebrates are encapsulated stretch receptors with structurally specialized intrafusal muscle fibers, innervated with sensory and fusimotor nerve endings (Barker and Cope, 1962; Boyd, 1962; Matthews, 1964; Barker et al., 1972). There are many detailed studies on the development of muscle spindles in several animal species and man (Sutton, 1915; Tello, 1917, 1922; Cuajunco 1927, 1940; Hewer, 1935; Zelená, 1957, 1959, 1976; Mavrinskaia, 1960; Bowden, 1963; Schiaffino and Pierobon Bormioli, 1976). Those earlier works showed that the most important event during the development of muscle spindles was the arrival of the sensory nerve fibers into the muscle, and the event occurred in the early stage of gestation. Muscle spindle formation is initiated by the primary afferent nerve contact with a bundle of developing myotubes. In some species, muscle spindle formation is completed during the intrauterine period, but in rats the onset of muscle spindle differentiation is observed to occur at a late stage of gestation (Zelená, 1957, 1959; Marchand and Eldred, 1969; Landon, 1972; Milburn, 1973); and the formation of rat muscle spindles is completed early postnatally.


Muscle Spindle Masseter Muscle Masticatory Muscle Postnatal Development Disuse Atrophy 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Norihiko Maeda
    • 1
  • Koichi Osawa
    • 2
  • Tamuro Masuda
    • 2
  • Tsuyoshi Kawasaki
    • 3
  • Masayoshi Kumegawa
    • 1
  1. 1.Departments of Oral AnatomyJosai Dental UniversitySakadoJapan
  2. 2.Oral DiagnosisJosai Dental UniversitySakadoJapan
  3. 3.Oral SurgeryJosai Dental UniversitySakadoJapan

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