Endocarditis Prophylaxis

  • Nelson M. Gantz


The subject of endocarditis prophylaxis continues to stir controversy. Despite recommendations for prevention of endocarditis from committees of the American Heart Association,1 Working Party of the British Society for Antimicrobial Chemotherapy,2 and the Medical Letter,3 these guidelines are not based on controlled clinical studies. No such studies have been published or are likely to be forthcoming.


Infective Endocarditis Positive Blood Culture Rheumatic Fever Rheumatic Heart Disease Mitral Valve Prolapse 
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  1. 1.
    Shulman ST, Amren DP, Bisno AL, et al: Prevention of bacterial endocarditis. Circulation 1984; 70: 1123A - 1127A.PubMedGoogle Scholar
  2. 2.
    Working Party of the British Society for Antimicrobial Chemotherapy: The antibiotic prophylaxis of infective endocarditis. Lancet 1982; 2: 1323 - 1326.Google Scholar
  3. 3.
    Medical Letter: Prevention of bacterial endocarditis. Med Lett 1986; 28: 22 - 25.Google Scholar
  4. 4.
    Bayliss R, Clarke C, Oakley C, et al: The teeth and infective endocarditis. Br Heart J 1983; 50: 506 - 512.PubMedCrossRefGoogle Scholar
  5. 5.
    Everett ED, Hirschmann JV: Transient bacteremia and endocarditis prophylaxis. A review. Medicine (Baltimore) 1977; 56: 61 - 77.Google Scholar
  6. 6.
    Sipes JN, Thompson RL, Hook EW: Prophylaxis of infective endocarditis: A reevaluation. Annu Rev Med 1977; 28: 371 - 391.PubMedCrossRefGoogle Scholar
  7. 7.
    Lowy F, Steigbigel NH: Infective endocarditis. Part III. Prevention of bacterial endocarditis. Am Heart J 1978; 96: 689 - 695.PubMedCrossRefGoogle Scholar
  8. 8.
    Kaye D: Prophylaxis against bacterial endocarditis: A dilemma in infective endocarditis. In: Kaplan EL, Taranta AV, eds. Infective Endocarditis. American Heart Association Monograph Series, No. 52. Dallas, American Heart Association, 1977: 67 - 69.Google Scholar
  9. 9.
    Garrod LP, Waterworth PM: The risks of dental extraction during penicillin therapy. Br Heart J 1962; 24: 39 - 46.PubMedCrossRefGoogle Scholar
  10. 10.
    Guntheroth WG: How important are dental procedures as a cause of infective endocarditis? Am J Cardiol 1984; 54: 797 - 801.PubMedCrossRefGoogle Scholar
  11. 11.
    Shorvan PJ, Eykyn SJ, Cotton PB: Gastrointestinal instrumentation, bacteremia, and endocarditis. Gut 1983; 24: 1078 - 1093.CrossRefGoogle Scholar
  12. 12.
    Sullivan NM, Sutter VL, Mims MM, et al: Clinical aspects of bacteremia after manipulation of the genitourinary tract. J Infect Dis 1973; 127: 49 - 55.PubMedCrossRefGoogle Scholar
  13. 13.
    Clemens JD, Horowitz RI, Jaffe CC, et al: A controlled evaluation of the risk of bacterial endocarditis in persons with mitral-valve prolapse. N Engl J Med 1982; 307: 776 - 781.PubMedCrossRefGoogle Scholar
  14. 14.
    Durack DT, Bisno AL, Kaplan EL: Apparent failures of endocarditis prophylaxis. Analysis of 52 cases submitted to a national registry. JAMA 1983; 250: 2318 - 2322.Google Scholar
  15. 15.
    Bor DH, Himmelstein DU: Endocarditis prophylaxis for patients with mitral valve prolapse. A quantitative analysis. Am J Med 1984; 76: 711 - 717.PubMedCrossRefGoogle Scholar
  16. 16.
    Schwartz SP, Salman I: The effect of oral surgery on the course of patients with disease of the heart. Am J Orthodont 1942; 28: 331 - 345.Google Scholar
  17. 17.
    Taran LM: Rheumatic fever in relation to dental disease. NY J Dent 1944; 14: 107 - 113.Google Scholar
  18. 18.
    Garrison PK, Freedman LR: Experimental endocarditis I: Staphylococcal endocarditis resulting from placement of a polyethylene catheter in the right side of the heart. Yale J Biol Med 1970; 42: 394 - 410.PubMedGoogle Scholar
  19. 19.
    Durack DT, Petersdorf RG: Chemotherapy of experimental streptococcal endocarditis: I. Comparison of commonly recommended prophylactic regimens. J Clin Invest 1973; 52: 592 - 598.PubMedCrossRefGoogle Scholar
  20. 20.
    Kaye D: Prophylaxis for infective endocarditis: An update. Ann Intern Med 1986; 104: 419 - 423.PubMedCrossRefGoogle Scholar
  21. 21.
    Durack DT: Current issues in prevention of infective endocarditis. Am J Med 1985; 78 (Suppl. 6B): 149 - 156.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

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  • Nelson M. Gantz

There are no affiliations available

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