Physical Modification of α-Cyanoacrylate for Application as Surgical Adhesives

  • Yin-Chao Tseng
  • Suong-Hyu Hyon
  • Yoshito Ikada


Lactide-ε-caprolactone copolymers [P(LA-co-CL)] were added to α-cyanoacrylates [CA] for thickening CA and plasticizing the resulting polymer. In addition to the viscosity, the set time, the spreading in blood, the bond strength of CA, and the stiffness of CA polymers were determined after CA mixing with P(LA-co-CL). The pressure-diameter relation for canine femoral arteries coated with CA was utilized to determine the stiffness parameter of the CA polymers. Furthermore, growth inhibition of Swiss 3T3 cells was tested using microspheres of the mixtures. It was found that the longer the side chain of CA, the lower was the stiffness of the polymer. With the increasing amount of P(LA-co-CL) in the mixture, the stiffness parameter decreased, while both the viscosity and the set time of CA increased. There was no difference in the bond strength, in vivo, between the pure CA and the CA mixed with the various concentrations of P(LA-co-CL) up to 15 wt.%. The copolymer addition to CA significantly reduced the cell growth inhibition of CA.


Bond Strength Cell Growth Inhibition Stiffness Parameter Anionic Polymerization Surgical Adhesive 
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  1. 1.
    A. C. Nassif, J. Surg. Res., 5, 108 (1965).CrossRefGoogle Scholar
  2. 2.
    V. A. Mcgraw & R. G. Caffesse, J. West. Soc. Periodont, 26, 4 (1978).Google Scholar
  3. 3.
    J. A. O’Leary, J. Surg. Oncol., 3, 117 (1971).CrossRefGoogle Scholar
  4. 4.
    C. G. Drake, Clin. Neurosurg., 26, 145 (1979).Google Scholar
  5. 5.
    A. J. Luessenhop & L. Rosa, J. Neurosurg., 60, 14 (1984).CrossRefGoogle Scholar
  6. 6.
    K. A. Galil, I. D. Schofield & G. A. Wright, Can. Dent. Assoc. J., 50, 565 (1984).Google Scholar
  7. 7.
    U.S. Patent 2,784,127; assigned to Eastman Kodak Company.Google Scholar
  8. 8.
    Japanese Patent 1973-10379.Google Scholar
  9. 9.
    Y.-C Tseng, S.-H Hyon, Y. Ikada, Y. Shimizu, K. Tamura & S. Hitomi, “The 35th symposium on Adhesion and Adhesives”, Adhesion Society of Japan, Tokyo, Japan, July 1987, p. 17.Google Scholar
  10. 10.
    C. G. Pitt, A. R. Jeffcoat, R. A. Zweidinger & A. Schindler, J. Biomed. Mater. Res., 13, 497 (1979).CrossRefGoogle Scholar
  11. 11.
    C. G. Pitt, M. M. Gratzl, G. L. Kimmel, J. Surles & A. Schindler, Biomaterials, 2, 215 (1981).CrossRefGoogle Scholar
  12. 12.
    R. M. Rice, A. F. Hegyeli, S. J. Gourlay, C. W. R. Wade, J. G. Dillon, H. Jaffe & R. K. Kulkarni, J. Biomed. Mater. Res., 12, 43 (1987).CrossRefGoogle Scholar
  13. 13.
    T. Nakamura, S. Hitomi, T. Shimamoto, S.-H. Hyon, Y. Ikada, S. Watanabe & Y. Shimizu, “Proc. Sixth European Conference on Biomaterials”, Bologna, Italy, September 1986, p. 759.Google Scholar
  14. 14.
    Y.-C. Tseng, S.-H. Hyon & Y. Ikada, The 35th Annual Meeting of the Society of Polymer Science of Japan, Kyoto, Japan, May 1986, p. 500.Google Scholar
  15. 15.
    C. A. Collins, K. C. Pani, R. A. Lehman & F. Leonard, Arch. Surg., 93, 428 (1966).CrossRefGoogle Scholar
  16. 16.
    K. Hayashi, H. Handa, S. Nagasawa, A. Okumura & K. Moritake, J. Biomech., 13, 175 (1980).CrossRefGoogle Scholar
  17. 17.
    K. Hayashi & Nakamura, J. Biomed. Mater. Res., 19, 133 (1985).CrossRefGoogle Scholar
  18. 18.
    D. S. Johnston & D. C. Pepper, Makromol. Chem., 182, 393 (1981).CrossRefGoogle Scholar
  19. 19.
    L. R. Beck, D. R. Cowsar, D. H. Lewis, R. J. Cosgrove, C. T. Riddle & S. L. Epperly, Fertil. Steril., 31, 545 (1979).Google Scholar
  20. 20.
    S.-H. Hyon, T. Nakamura, K. Jamshidi, T. Yamamoto & Y. Ikada, “China-Japan Bilateral Symposium on the Synthesis and Materials Science of Polymers”, Academia Sinica, China, and the Society of Polymer Science, Japan, Beijing, China, October 1984, p. 369.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Yin-Chao Tseng
    • 1
  • Suong-Hyu Hyon
    • 1
  • Yoshito Ikada
    • 1
  1. 1.Research Center for Medical Polymers and BiomaterialsKyoto UniversityShogoin, Sakyo-ku, Kyoto 606Japan

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