Evaluation of the Tissue-Protective Properties of Hydrophilic Surface Modified Intraocular Lens Implants
Since damage to fragile ocular tissues by surface interaction with ocular implant materials can seriously compromise the biocompatibility of intraocular lenses, we have developed endothelium and iris damage tests for evaluating new materials. This paper describes such studies on new hydrophilic polymer surface modified intraocular lenses. In addition to endothelium damage assessment, a new iris abrasion test was developed to evaluate differences in abrasion of the iris by ocular implant polymers. The primary intraocular lens (IOL) polymer in current use, poly(methyl methacrylate) (PMMA), was compared with a novel surface modified PMMA having a permanent, chemically bound, hydrophilic polymer surface. Results indicate a major reduction in endothelium damage and iris abrasion by the hydrophilic surface modification of PMMA.
KeywordsEndothelium Damage Intraocular Lens Rabbit Corneal Endothelium PMMA IOLs Test Lens
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