Evaluation of the Tissue-Protective Properties of Hydrophilic Surface Modified Intraocular Lens Implants

  • F. M. Hofmeister
  • M. Yalon
  • S. Iida
  • J. Stacholy
  • E. P. Goldberg

Abstract

Since damage to fragile ocular tissues by surface interaction with ocular implant materials can seriously compromise the biocompatibility of intraocular lenses, we have developed endothelium and iris damage tests for evaluating new materials. This paper describes such studies on new hydrophilic polymer surface modified intraocular lenses. In addition to endothelium damage assessment, a new iris abrasion test was developed to evaluate differences in abrasion of the iris by ocular implant polymers. The primary intraocular lens (IOL) polymer in current use, poly(methyl methacrylate) (PMMA), was compared with a novel surface modified PMMA having a permanent, chemically bound, hydrophilic polymer surface. Results indicate a major reduction in endothelium damage and iris abrasion by the hydrophilic surface modification of PMMA.

Keywords

Endothelium Damage Intraocular Lens Rabbit Corneal Endothelium PMMA IOLs Test Lens 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J. Katz, H. E. Kaufman, E. P. Goldberg & J. W. Sheets, Trans. AAO, 83, 204–212 (1977). “Prevention of Endothelium Damage from Intraocular Lens Insertion.”.Google Scholar
  2. 2.
    H. E. Kaufman, J. Katz, J. Valenti, J. W. Sheets & E. P. Goldberg, Science, 198, 525–527 (1977). “Corneal Endothelium Damage with Intraocular Lenses: Contact Adhesion Between Surgical Materials and Tissue.”.CrossRefGoogle Scholar
  3. 3.
    M. Yalon, J. W. Sheets, S. Reich & E. P. Goldberg, ACTA XXIV Congress Ophth., P. Henkind, Ed., J. P. Lippincott, Philadelphia, 1983. “Quantitative Aspects of Endothelium Damage Due to Intraocular Lens Contacts: Effect of Hydrophilic Polymer Graft Coatings.”.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • F. M. Hofmeister
    • 1
  • M. Yalon
    • 1
  • S. Iida
    • 1
  • J. Stacholy
    • 1
  • E. P. Goldberg
    • 1
  1. 1.Biomedical Engineering CenterUniversity of Florida-MAE 217GainesvilleUSA

Personalised recommendations