Advertisement

Biological Characterization of Selected Palladium (II) Poly(amides), Poly(thioamides) and Poly(hydrazides)

  • Charles E. CarraherJr.
  • Weimin Chen
  • George G. Hess
  • David J. Giron

Abstract

A number of palladium-containing polymers were tested biologically for their ability to inhibit HF5 (normal), HeLa (human cervical carcinoma), Hep-2 (human laryngeal carcinoma) and Girardi human heart (transformed) cells. There appears to be a direct relationship between the inhibition exhibited by the monomeric diamine and the corresponding polymer. In most cases, Inhibition was superior to that observed for cis-DDP.

Keywords

Reactant Concentration Azelaic Acid Glutaric Acid Biological Characterization Human Cervical Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    B. Rosenberg, L. Van Camp, J. Trosko & V. Mansour, Nature, 222, 385 (1969).CrossRefGoogle Scholar
  2. 2.
    C. Carraher, W. Scott & D. Giron in: “Bioactive Polymeric Systems,” (C. G. Gebelein & C. E. Carraher, Eds.), Plenum, New York, 1985, Chapter 20.Google Scholar
  3. 3.
    C. Carraher, I. Lopez & D. Giron in: “Advances in Biomedical Polymers,” (C. G. Gebelein, Ed.), Plenum, New York, 1987, p. 311.CrossRefGoogle Scholar
  4. 4.
    C. Carraher, C. Ademu-John, J. Fortman, D. Giron & C. Turner, J. Polym. Mater., 1, 116 (1984).Google Scholar
  5. 5.
    C. Carraher, W. Scott & J. Schroeder, J. Macromol. Sci.-Chem., A15 (4), 625 (1981).Google Scholar
  6. 6.
    C. Carraher, A. Gasper, M. Trombley, F. Deroos, D. Giron, G. Hess & K. Casberg in: “New Monomers and Polymers,” (B. Culbertson & C. Pittman), Plenum, New York, 1983, Chapter 9.Google Scholar
  7. 7.
    F. A. Cotton & G. Wilkerson, “Advanced Inorganic Chemistry,” John Wiley, New York, 1972.Google Scholar
  8. 8.
    J. R. Durig & B. R. Mitchell, Applied Spectroscopy, 21, 4 (1967).CrossRefGoogle Scholar
  9. 9.
    F. Basolo & R. G. Pearson, “Mechanisms of Inorganic Reactions,” 11th Ed., Wiley, New York, 1967.Google Scholar
  10. 10.
    R. D. Graham & D. R. Williams, Inorg. Chem., 41, 1245 (1979).Google Scholar
  11. 11.
    C. Carraher, W. Chen, G. Hess & M. Williams, unpublished results.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Charles E. CarraherJr.
    • 1
    • 2
  • Weimin Chen
    • 1
    • 2
  • George G. Hess
    • 1
    • 2
  • David J. Giron
    • 1
    • 2
  1. 1.Departments of Chemistry and Microbiology and ImmunologyWright State UniversityDaytonUSA
  2. 2.Florida Atlantic UniversityBoca RatonUSA

Personalised recommendations