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The Ability of Norgestomet Impregnated Poly(dimethylsiloxane) Implants to Maintain Pregnancy Subsequent to Ovariectomy

  • R. J. Favero
  • E. A. Henderson
  • D. J. Kesler

Abstract

Poly(dimethylsiloxane) has been used to deliver steroids to animals since the 1960s and a commercial poly(dimethylsiloxane) based delivery system for estradiol is currently available for growth enhancement. Recent data collected in our laboratory demonstrated that poly(dimethylsiloxane) implants impregnated with norgestomet, a synthetic progestin, were capable of maintaining pregnancy in ovariectomized heifers. In the absence of an exogenous source of a progestin, ovariectomy would cause abortion or premature parturition in cattle. Ovariectomized heifers implanted with poly(dimethylsiloxane)/norgestomet implants had pregnancy rates similar to treated females not ovariectomized. Removal of the poly(dimethylsiloxane)/norgestomet implants late in gestation permitted the heifers to calve and offspring born were normal.

Keywords

Mammary Gland Corpus Luteum Ethylene Glycol Methacrylate Secretion Rate Testosterone Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • R. J. Favero
    • 1
    • 2
  • E. A. Henderson
    • 1
    • 2
  • D. J. Kesler
    • 1
    • 2
  1. 1.Physiology Research Laboratory, Reproductive Engineering & Biotechnology, Department of Animal SciencesUniversity of IllinoisUrbanaUSA
  2. 2.CEVA Laboratories, Inc.Overland ParkUSA

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