The Ability of Norgestomet Impregnated Poly(dimethylsiloxane) Implants to Maintain Pregnancy Subsequent to Ovariectomy

  • R. J. Favero
  • E. A. Henderson
  • D. J. Kesler


Poly(dimethylsiloxane) has been used to deliver steroids to animals since the 1960s and a commercial poly(dimethylsiloxane) based delivery system for estradiol is currently available for growth enhancement. Recent data collected in our laboratory demonstrated that poly(dimethylsiloxane) implants impregnated with norgestomet, a synthetic progestin, were capable of maintaining pregnancy in ovariectomized heifers. In the absence of an exogenous source of a progestin, ovariectomy would cause abortion or premature parturition in cattle. Ovariectomized heifers implanted with poly(dimethylsiloxane)/norgestomet implants had pregnancy rates similar to treated females not ovariectomized. Removal of the poly(dimethylsiloxane)/norgestomet implants late in gestation permitted the heifers to calve and offspring born were normal.


Mammary Gland Corpus Luteum Ethylene Glycol Methacrylate Secretion Rate Testosterone Concentration 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • R. J. Favero
    • 1
    • 2
  • E. A. Henderson
    • 1
    • 2
  • D. J. Kesler
    • 1
    • 2
  1. 1.Physiology Research Laboratory, Reproductive Engineering & Biotechnology, Department of Animal SciencesUniversity of IllinoisUrbanaUSA
  2. 2.CEVA Laboratories, Inc.Overland ParkUSA

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