Abstract
Flexible PVC has for many years provided a major contribution in the development, manufacture, and assembly of medical devices. The wealth of information available today regarding the performance of conventional PVC compounds underwrites their undoubted value, but also recognizes certain limitations. Exploiting its unique ability to accept an ever increasing range of material variables, PVC polymer systems can be engineered to extend performance boundaries. This paper identifies certain applications where the use of extraction resistance PVC compounds provides additional benefits. The properties of DEHP, TOTM and PA plasticized compounds are reviewed and the information presented includes recent data concerning extraction into biological fluids. Novel techniques developed elsewhere using in vitro and ex vivo procedures to assess the blood platelet response, immune response, and the influence of antithrombotic agents upon these compounds are reviewed with the accompanying results.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
“DEHP — A critical review and interpretation of the available toxicological information”, CEFIC, Brussels, September 1985.
E. G. Hayhurst & M. Wyman, Am. J. Dis. Children, 129, 72 (1975).
R. J. Jaeger & R. J. Rubin, New Engl. J. Med., 287, 1114 (1972).
T. P. Gibson, W. A. Briggs & B. J. Boone, J. Lab. Clin. Med., 87, 519 (1976).
M. S. Biggs & J. Baldwin, Plast. Rub. Mater. Appl., 5 (4), 187 (1980).
M. S. Biggs & D. Robson in: “Polymers in Medicine”, E. Chiellini & P. Giusti, Eds., Plenum Publishing Corp., 1984, p. 375.
“Transfusion Equipment for Medical Use”, British Standard Spec. 2463.
NHPL unpublished work, University of Newcastle upon Tyne Medical School, (February 1987).
NHPL unpublished work, North American Science Associates, Test Reports (1982).
J. M. Courtney, M. Travers, S. K. Bowry, C. R. M. Prentice, G. D. O. Lowe & C. D. Forbes, Biomaterials, 8, 231–233 (1987).
S. K. Bowry, J. M. Courtney, C. R. M. Prentice & J. T. Douglas, Biomaterials, 5, 289–292 (1984).
J. M. Courtney, M. Travers, D. L. Mwaniki, J. P. Paul, G. D. O. Lowe & C. D. Forbes, “Biomaterials and Clinical Applications”, A. Pizzoferrato, P. G. Marchetti, A. Ravaglioli & A. J. C. Lee, Eds., Elsevier, Amsterdam, 1987, pp. 771–776.
C. J. Ryan, J. M. Courtney, C. B. Wood, R. G. Hood & L. H. Blumgart, Brit. J. Exp. Path., 60, 400–404 (1979).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Blass, C.R. (1990). Medical Applications for Extraction Resistant PVC Compounds. In: Gebelein, C.G., Dunn, R.L. (eds) Progress in Biomedical Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0768-4_31
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0768-4_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0770-7
Online ISBN: 978-1-4899-0768-4
eBook Packages: Springer Book Archive