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Chitosan: A Biocompatible Material for Oral and Intravenous Administrations

  • Shigehiro Hirano
  • Haruyoshi Seino
  • Yasutoshi Akiyama
  • Isao Nonaka

Abstract

Chitosan is the N-deacetylated product of chitin {(1→4)-linked 2-acetamido-2-deoxy-β-D-glucan}, which is abundant in nature. (1) No abnormal symptom was observed with several animals when chitosan was orally administered at a dosage of 0.7–0.8 g/kg body weight/day for up to 239 days. (2) Apparent digestibility by rabbits was 28–38% for chitin and 39–79% for chitosan, and that both polymers were digested almost completely by hens and broilers. (3) No abnormal symptom was observed with rabbits when low-molecular-weight (LMW)-chitosan (MW about 3,000) or chitosan oligosaccharides (MW 304 – 1,162) were injected intravenously at a dosage of 4.5 mg/kg body weight/day for 7–11 days. (4) Hypocholesterolemic function was observed with chitosan administered orally but not with LMW-chitosan or oligosaccharides injected intravenously. These data strongly indicate that chitosan is usable as a novel carrier of drugs in the drug delivery system for oral and intravenous administration.

Keywords

Drug Delivery System Basal Ration Apparent Digestibility Biomedical Polymer Chitosan Oligosaccharide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Chitin and Chitosan”, Japan Soc. Chitin/Chitosan edition, Gihodo Co., Tokyo, 1988.Google Scholar
  2. 2.
    O. Konrrad, P. Gross, & H. Mager, JP, 58-3124 (1983); 59-40804 (1984).Google Scholar
  3. 3.
    Y. Chikamatsu & H. Ando, JP, 59-106409 (1984).Google Scholar
  4. 4.
    K. Kibune, Y. Yamaguchi, J. Yasumasa, & Y. Nobe, JP, 60-215855 (1985); 61-52872 (1986); 61-240963 (1986).Google Scholar
  5. 5.
    S. Hirano, Y. Noishiki, J. Kinugawa, H. Higashijima & T. Hayashi in: “Advances in Biomedical Polymers”, C. G. Gebelein, Ed., Plenum Press, New York, 1987, p. 285–297.CrossRefGoogle Scholar
  6. 6.
    S. Hirano, Y. Kondo, M. Fuketa, & A. Yamashita, Proc. Int. Con. Chitin/Chitosan, 2, 57–62 (1982).Google Scholar
  7. 7.
    M. Izume & A. Ohtakara, Agric. Biol. Chem., 51, 1189 (1987).CrossRefGoogle Scholar
  8. 8.
    G. Blix, Acta Chem. Scand., 2, 467 (1948).CrossRefGoogle Scholar
  9. 9.
    K. Arai, T. Kinumaki, & T. Fujita, Bull. Tokai Regional Fisheries Res. Lab., 56, 89–94 (1968).Google Scholar
  10. 10.
    S. Hirano, N. Sato, S. Yoshida, & S. Kitagwa in: “Industrial Polysaccharides” M. Yalpani, Ed., Elsevier Science Publishers, Amsterdam, 1987, p. 163–176.Google Scholar
  11. 11.
    S. Hirano, Y. Ohe Carbohydr. Polym., 4, 15 (1984).CrossRefGoogle Scholar
  12. 12.
    M. Sugano, T. Fujikawa, Y. Hiratsuji & Y. Hasegawa, Nutr. Rep. Int., 18, 531 (1978).Google Scholar
  13. 13.
    S. Suzuki, Y. Okawa, Y. Okura, K. Hashimoto & K. Suzuki, Chitin & Chitosan. Proc. Int. Conf. 2, 210 (1983).Google Scholar
  14. 14.
    S. Hirano & M. Hayashi, Polym. Mater. Sci. Eng., 57, 38 (1987).Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Shigehiro Hirano
    • 1
  • Haruyoshi Seino
    • 1
  • Yasutoshi Akiyama
    • 1
  • Isao Nonaka
    • 1
  1. 1.Department of Agricultural BiochemistryTottori UniversityTottori 680Japan

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