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Biodegradable Polyamides Based on 4,4′-Spirobibutyrolactone

  • David P. Vanderbilt
  • James P. English
  • Glenda L. Fleming
  • Gerald W. McNeely
  • Donald R. Cowsar
  • Richard L. Dunn

Abstract

This paper describes the synthesis, structure, and some properties of a new family of biodegradable poly(amides) based on 4,4′-spirobibutyrolactone (SBBL). The polymers were synthesized using melt polymerization techniques similar to those used to prepare nylon 6,6. Both homopolymers (SBBL + diamine) and block copolymers (SBBL + diamine + nylon salt) were prepared. The homopolymer and copolymer backbones contain lactam and spirolactam groups in addition to the expected secondary amide groups. Homopolymers were found to degrade completely in neutral phosphate buffer, while the block copolymers degraded only partially in vitro and in vivo. The copolymers evoked only a mild tissue response when implanted subcutaneously in rabbits. Other properties of this unusual family of polymers are discussed.

Keywords

Block Copolymer Glutaric Acid Secondary Amide Azeotropic Distillation Lactone Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • David P. Vanderbilt
    • 1
  • James P. English
    • 2
  • Glenda L. Fleming
    • 3
  • Gerald W. McNeely
    • 4
  • Donald R. Cowsar
    • 1
  • Richard L. Dunn
    • 5
  1. 1.Southern Research InstituteBirminghamUSA
  2. 2.Birmingham Polymers, Inc.BirminghamUSA
  3. 3.University of Alabama at BirminghamBirminghamUSA
  4. 4.Hoechst Fiber IndustriesSpartanburgUSA
  5. 5.Vipont Research Laboratories, Inc.Ft. CollinsUSA

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