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Progress in Biomedical Polymers pp 171–178Cite as

The Poly(nonapeptide) of Elastin: A New Elastomeric Polypeptide Biomaterial

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Abstract

This paper reports the first data on a new member of the class of elastomeric polypeptide biomaterials. The new member is poly(VPGFGVGAG). The synthesis is demonstrated by carbon-13 and proton nuclear magnetic resonance spectra; the temperature ranges for the inverse temperature transition have determined by temperature profiles for turbidity formation (aggregation); and the material has been crosslinked by γ-irradiation to produce elastomeric matrices. Poly(VPGFGVGAG) is distinguished from elastomeric poly(VPGVG) and poly(VPGG) by exhibiting a greater elastic modulus for the same cross-linking treatment, some two orders of magnitude larger, and by simultaneously being chemotactic toward endothelial cells and fibroblasts. These properties appear to be particularly appropriate for consideration of this bioelastic as a scaffolding for the reconstruction of ligaments.

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Abbreviations

Boc:

tert-butyloxycarbonyl

OBzl:

benzyl ester

DMF:

dimethylformamide

DMSO:

dimethylsulfoxide

EDe:

1 ethyl-3-dimethylaminopropyl carbodiimide

HOBt:

1-hydroxybenzotriazole

IBCF:

isobutylchloroformate

NMM:

N-methylmorpholine

ONp:

p-nitrophenyl ester

TFA:

trifluoroacetic acid

A:

alanine

G:

glycine

F:

phenylalanine

P:

proline

V:

valine

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Author information

Authors and Affiliations

  1. Laboratory of Molecular Biophysics, School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA

    Dan W. Urry, John Jaggard, R. Dean Harris, D. K. Chang & Kari U. Prasad

Authors
  1. Dan W. Urry
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  2. John Jaggard
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  3. R. Dean Harris
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  4. D. K. Chang
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  5. Kari U. Prasad
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Editor information

Editors and Affiliations

  1. Department of Chemistry, Youngstown State University, Youngstown, Ohio, USA

    Charles G. Gebelein

  2. Atrix Laboratories, Inc., Fort Collins, Colorado, 80525, USA

    Richard L. Dunn

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© 1990 Springer Science+Business Media New York

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Urry, D.W., Jaggard, J., Harris, R.D., Chang, D.K., Prasad, K.U. (1990). The Poly(nonapeptide) of Elastin: A New Elastomeric Polypeptide Biomaterial. In: Gebelein, C.G., Dunn, R.L. (eds) Progress in Biomedical Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0768-4_18

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  • DOI: https://doi.org/10.1007/978-1-4899-0768-4_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0770-7

  • Online ISBN: 978-1-4899-0768-4

  • eBook Packages: Springer Book Archive

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