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Carbonic Anhydrase Kinetics and Molecular Function

  • Chapter
The Carbonic Anhydrases

Abstract

Detailed kinetic and mechanistic studies of the zinc metalloenzyme carbonic anhydrase (CA) became possible only after the discovery of its existence in the form of two distinct though homologous erythrocyte isozymes, CA I and CA II. For a comprehensive early review of the structure and function of CA, see reference 72. Studies in the last decade have led to the discovery of the low-specific-activity CA III in skeletal muscle that has now been kinetically investigated. Other CA isozymes (IV–VII) have now also been identified102 but have not been sufficiently characterized by kinetics to cover here.

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Author information

Authors and Affiliations

  1. Biochemistry Department, Kansas University Medical School, and Research Service, Veterans Administration Medical Center, Kansas City, Missouri, 64128, USA

    Raja G. Khalifah

  2. Department of Pharmacology, University of Florida College of Medicine, Gainesville, Florida, 32610, USA

    David N. Silverman

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  1. Raja G. Khalifah
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Editors and Affiliations

  1. Department of Physiology, School of Medicine, University of Pennsylvania, 19104-6085, Philadelphia, Pennsylvania, USA

    Susanna J. Dodgson

  2. Department of Human Genetics, University of Michigan Medical School, 48109-0618, Ann Arbor, Michigan, USA

    Richard E. Tashian

  3. Zentrum Physiologie, Medizinische Hochschule Hannover, 3000, Hannover 61, Federal Republic of Germany

    Gerolf Gros

  4. Department of Child Health, St. George’s Hospital Medical School, University of London, SW17 ORE, London, UK

    Nicholas D. Carter

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Khalifah, R.G., Silverman, D.N. (1991). Carbonic Anhydrase Kinetics and Molecular Function. In: Dodgson, S.J., Tashian, R.E., Gros, G., Carter, N.D. (eds) The Carbonic Anhydrases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0750-9_4

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