Localization of Carbonic Anhydrase Isozymes in Calcified Tissues

  • H. Kalervo Väänänen
  • Eeva-Kaisa Parvinen


Carbonic anhydrase (CA) has been shown to be associated with the calcification process in invertebrates as well as in vertebrates. In several invertebrate species, including molluscs, calcareous sponges, corals, crabs, echinoderms, and barnacles, CA activity has been directly connected to calcification.3,4,13,14,17,18,19,24 Thefunction of the CAs in the mineralization of different invertebrates as well as in egg shell calcification is supported by several studies demonstrating decrease or inhibition of the calcification rate by CA inhibitors.6,9,16,21,38 CA may also function in decalcifying hen egg shells.32


Carbonic Anhydrase Calcify Tissue Hypertrophic Chondrocytes Carbonic Anhydrase Activity Matrix Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Anderson, R. E., Jee, W. S. S., and Woodbury, D. M., 1985, Calcif. Tissue Int. 37: 646–650.PubMedCrossRefGoogle Scholar
  2. 2.
    Anderson, R. E., Schraer, H., and Gay, C. V, 1982, Anat. Rec. 204: 9–20.PubMedCrossRefGoogle Scholar
  3. 3.
    Boer, H. H., and Witteveen, J., 1980, Calcif. Tissue Res. 209: 383–390.Google Scholar
  4. 4.
    Cameron, J. N., and Wood, C. M., 1985, J. Exp. Biol. 114: 181–196.Google Scholar
  5. 5.
    Cao, H., and Gay, C. V, 1985, Experientia 41: 1472–1474.PubMedCrossRefGoogle Scholar
  6. 6.
    Costlow, J. D., 1959, Physiol. Zoo!. 32: 177–184.Google Scholar
  7. 7.
    Cuervo, L. A., Pita, J. C., and Howell, D. S., 1981, Calcif. Tissue Res. 7: 220–231.CrossRefGoogle Scholar
  8. 8.
    Dogterom, A. A., Vervoets, T. J. M., Lyaruu, D. M., and Wöltgens, J. H. M., 1983, J. Biol. Buccale 11: 15–21.PubMedGoogle Scholar
  9. 9.
    Freeman, J. A., 1960, Biol. Bull. 118: 412–418.CrossRefGoogle Scholar
  10. 10.
    Gay, C. V, and Müller, W. J., 1974, Science 183: 432–434.PubMedCrossRefGoogle Scholar
  11. 11.
    Gay, C. V, Anderson, R. E., Schraer, H., and Howell, D. S., 1982, J. Histochem. Cytochem. 30: 391–394.PubMedCrossRefGoogle Scholar
  12. 12.
    Gay, C. V, Ito, M. B., and Schraer, H., 1983, Metab. Bone Dis. Rel. Res. 5: 33–39.CrossRefGoogle Scholar
  13. 13.
    Giraud, M. M., 1981, Comp. Biochem. Physiol. 69: 381–387.CrossRefGoogle Scholar
  14. 14.
    Goreau, T. F., 1959, Biol. Bull. 116: 59–75.CrossRefGoogle Scholar
  15. 15.
    Hall, G. E., and Kenny, A. D., 1987, Calcif. Tissue Int. 40: 212–218.PubMedCrossRefGoogle Scholar
  16. 16.
    Heatfield, B. M., 1970, Biol. Bull. 139: 151–163.CrossRefGoogle Scholar
  17. 17.
    Henry, R. P, 1984, Ann. N.Y. Acad. Sci. 429: 544–546.PubMedCrossRefGoogle Scholar
  18. 18.
    Henry, R. P, and Kormanik, G. A., 1985, J. Crust. Biol. 5: 234–241.CrossRefGoogle Scholar
  19. 19.
    Henry, R. P, and Saintsing, D. G., 1983, Physiol. Zool. 56: 274–280.Google Scholar
  20. 20.
    Jilka, R. L., Rogers, J. I., Khalifah, R. G., and Väänänen, H. K., 1985, Bone 6: 445–449.PubMedCrossRefGoogle Scholar
  21. 21.
    Jones, W. C., and Ledger, P. W, 1986, Comp. Biochem. Physiol. 84: 149–158.CrossRefGoogle Scholar
  22. 22.
    Kenny, A. D., 1972, Proc. Soc. Exp. Biol. Med. 140: 135–139.PubMedGoogle Scholar
  23. 23.
    Kenny, A. D., 1985, Calcif. Tissue Int. 37: 126–133.PubMedCrossRefGoogle Scholar
  24. 24.
    Kingsley, R. J., and Watabe, N., 1987, J. Exp. Zool. 241: 171–180.CrossRefGoogle Scholar
  25. 25.
    Kumpulainen, T., and Väänänen, H. K., 1982, Calcif. Tissue Int. 34: 428–430.PubMedCrossRefGoogle Scholar
  26. 26.
    Marie, J. P, and Hott, M., 1987, J. Histochem. Cytochem. 35: 245–250.PubMedCrossRefGoogle Scholar
  27. 27.
    Minkin, C., and Jennings, J. M., 1972, Science 176: 1031–1033.PubMedCrossRefGoogle Scholar
  28. 28.
    Parvinen, E. K., 1990, Acta Histochemica, (in press).Google Scholar
  29. 29.
    Raisz, L. G., Simmons, H. A., Thompson, W. J., Shepard, K. L., Anderson, P S., and Rodan, G. A., 1988, Endocrinology 122: 1083–1086.PubMedCrossRefGoogle Scholar
  30. 30.
    Silverton, S. E, Dodgson, S. J., Fallon, M. D., and Forster, R. E., B1,1987, Am. J. Physiol. 253: E670–674.Google Scholar
  31. 31.
    Sundquist, K. T., Leppilampi, M., Järvelin, K., Kumpulainen, T., and Väänänen, H. K., 1987, Bone 8: 33–38.PubMedCrossRefGoogle Scholar
  32. 32.
    Mitan, R. S., 1984, Ann. N.Y. Acad. Sci. 429: 459–472.CrossRefGoogle Scholar
  33. 33.
    Väänänen, H. K., 1984, Histochemistry 81: 485–487.PubMedCrossRefGoogle Scholar
  34. 34.
    Väänänen, H. K., and Korhonen, L. K., 1984, in: Methods of Calcified Tissue Preparation (G. Dickson, ed.) Elsevier, Amsterdam, pp. 309–332.Google Scholar
  35. 35.
    Vaänänen, H. K., and Parvinen, E.-K., 1983, Histochemistry 78: 481–485.PubMedCrossRefGoogle Scholar
  36. 36.
    Väänänen, H. K., and Tuukkanen, J.,1986, in: Cell Mediated Calcification and Matrix Vesicles (S. Y. Ali, ed.), Elsevier Science Publishers, B. V. (Biomedial Division ), Amsterdam, pp. 143–146.Google Scholar
  37. 37.
    Waite, L. C., Volkert, W. A., and Kenny, A. D., 1970, Endocrinology 87: 1129–1139.PubMedCrossRefGoogle Scholar
  38. 38.
    Yule, A. B., Crisp, D. J., and Cotton, I. H., 1982, Mar. Biol. Lett. 3: 273–288.Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • H. Kalervo Väänänen
    • 1
  • Eeva-Kaisa Parvinen
    • 1
  1. 1.Department of AnatomyUniversity of OuluOuluFinland

Personalised recommendations