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Hormonal Regulation and Localization of Rat Liver Carbonic Anhydrase

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The Carbonic Anhydrases

Abstract

The first reports that rat liver contained endogenous carbonic anhydrase (CA)4,11 indicated that the CO2 hydrase activity of liver CA was poorly inhibited by acetazolamide compared with the strong inhibition of rat red cell CAs (CA I and CA II). A partial purification of CA from the liver of male rats showed that the specific CO2 hydrase activity of this acetazolamide-resistant form was approximately 1% of CA H purified from rat red cells.5 The livers of male rats contained far more of the sulfonamide-refractory form of CA than did the livers of female rats. However, female rat livers were richer than male livers in a “high-activity” sulfonamide-sensitive CA. Testosterone apparently induced the male type CA.4

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References

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Author information

Authors and Affiliations

  1. Department of Child Health, St. George’s Hospital Medical School, University of London, London, SW17 ORE, UK

    Stephen Jeffery

Authors
  1. Stephen Jeffery
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Editor information

Editors and Affiliations

  1. Department of Physiology, School of Medicine, University of Pennsylvania, 19104-6085, Philadelphia, Pennsylvania, USA

    Susanna J. Dodgson

  2. Department of Human Genetics, University of Michigan Medical School, 48109-0618, Ann Arbor, Michigan, USA

    Richard E. Tashian

  3. Zentrum Physiologie, Medizinische Hochschule Hannover, 3000, Hannover 61, Federal Republic of Germany

    Gerolf Gros

  4. Department of Child Health, St. George’s Hospital Medical School, University of London, SW17 ORE, London, UK

    Nicholas D. Carter

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© 1991 Springer Science+Business Media New York

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Jeffery, S. (1991). Hormonal Regulation and Localization of Rat Liver Carbonic Anhydrase. In: Dodgson, S.J., Tashian, R.E., Gros, G., Carter, N.D. (eds) The Carbonic Anhydrases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0750-9_24

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  • DOI: https://doi.org/10.1007/978-1-4899-0750-9_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0752-3

  • Online ISBN: 978-1-4899-0750-9

  • eBook Packages: Springer Book Archive

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