Structure and Expression of the Carbonic Anhydrase III Gene

  • Yvonne H. Edwards


Carbonic anhydrase (CA) has evolved into at least six separate forms, CA I to CA VI (for reviews, see references 36 and 37). Structural comparisons at both the protein and DNA levels show that the CA gene family has expanded from a single ancestral gene by the process of duplication; this origin is further evidenced by chromosomal synteny of at least three of the CA genes. The close linkage of mouse CA1 and CA2 near the centromere of chromosome 3 was reported more than a decade ago.12 More recently, we have shown by linkage analysis and in situ hybridization that mouse CA3 maps to the same region.1 Similarly, the human CA1, CA2, and CA3 genes have been shown to be clustered on the long arm of chromosome 8 at g22.7,9,10,28 The probable presence of CA I, CA II, and CA III isoforms in birds and reptiles suggests that the duplicated CA genes have maintained linkage for more than 300 million years. It is not clear why this linkage has been retained and whether the chromosomal proximity of the CA genes plays any part in their widely diverse patterns of expression.


Carbonic Anhydrase Human Carbonic Anhydrase Single Ancestral Gene eDNA Probe Mononucleate Myoblast 
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  1. 1.
    Beechey, C., Liveedie, S., Spurr, N., Peters, J., and Edwards, Y., 1990, Genomics 4: 672–696.Google Scholar
  2. 2.
    Bird, A. P, 1986, Nature (London) 321: 209–213.Google Scholar
  3. 3.
    Bird, A., Taggart, M., Nicholls, R., and Higgs, D., 1987, EMBO J. 6: 999–1004.PubMedGoogle Scholar
  4. 4.
    Brownson, C., Isenberg, H., Brown, W, Salmons, S., and Edwards, Y., 1988, Muscle Nerve 11: 1183–1189.PubMedCrossRefGoogle Scholar
  5. 5.
    Caravatti, M., Minty, A., Robert, B., Montarras, D., Weydert, A., Cohen, A., Daubas, P., and Buckingham, M., 1982, J. Mol. Biol. 160: 59–76.PubMedCrossRefGoogle Scholar
  6. 6.
    Carter, N., Hewett-Emmett, D., Jeffery, S., and Tashian, R., 1981, FEBS Len. 128: 114–118.CrossRefGoogle Scholar
  7. 7.
    Davis, M., West, L., Barlow, J., Butterworth, P. H. W, Lloyd, J., and Edwards, Y. H., 1987, Somat. Cell Mol. Genet. 13: 173–178.Google Scholar
  8. 8.
    Edwards, Y. H., 1990, Phil. Trans. R. Soc. 326: 207–215.CrossRefGoogle Scholar
  9. 9.
    Edwards, Y. H., Barlow, J. M., Konialias, C. P., Povey, S., and Butterworth, P. H., 1986, Ann. Hum. Genet. 50: 123–129.PubMedCrossRefGoogle Scholar
  10. 10.
    Edwards, Y. H., Lloyd, J., Parkar, M., and Povey, S., 1986, Ann. Hum. Genet. 50: 41–47.PubMedCrossRefGoogle Scholar
  11. 11.
    Edwards, Y. H., Charlton, J., and Brownson, S., 1988, Gene 71: 473–481.PubMedCrossRefGoogle Scholar
  12. 12.
    Eicher, E. M., Stern, R. H., Womack, J. E., Davisson, M. T., Roderick, T. H., and Reynolds, S. C., 1976, Biochem. Genet. 14: 651–660.PubMedCrossRefGoogle Scholar
  13. 13.
    Eriksson, A. E., and Liljas, A., this volume, Chapter 3.Google Scholar
  14. 14.
    Fremont, P, Charcot, P, Cote, C., and Rogers, P, 1988, J. Histochem. Cytochem. 36: 775–782.PubMedCrossRefGoogle Scholar
  15. 15.
    Geers, C., and Gros, G., this volume, Chapter 19.Google Scholar
  16. 16.
    Glass, C., Holloway, J., Devary, O., and Rosenfeld, M., 1988, Cell 54: 313–323.PubMedCrossRefGoogle Scholar
  17. 17.
    Jaynes, J., Johnson, J., Buskin, J., Gartside, C., and Hauschka, S., 1988, Mol. Cell. Biol. 8: 62–70.PubMedGoogle Scholar
  18. 18.
    Jeffery, S., Edwards, Y., and Carter, N., 1980, Biochem. Genet. 18: 843–849.PubMedCrossRefGoogle Scholar
  19. 19.
    Jeffery, S., Wilson, C. A., Mode, A., Gustafsson, J.-A., and Carter, N., 1986, J. Endocrinol. 110: 123–126.PubMedCrossRefGoogle Scholar
  20. 20.
    Kadonaga, J., Jones, K., and Tjian, R., 1986, Trends Biochem. Soc. 11: 20–23.CrossRefGoogle Scholar
  21. 21.
    Kelly, C., Carter, N., Jeffery, S., and Edwards, Y., 1988, Biosci. Rep. 3: 401–406.CrossRefGoogle Scholar
  22. 22.
    Koenig, R., Brent, G., Warne, R., Larsen, P., and Moore, D., 1984, Proc. Natl. Acad. Sci. USA 84: 5670–5674.Google Scholar
  23. 23.
    Lloyd, J., McMillan, S., Hopkinson, D. A., and Edwards, Y., 1986, Gene 41: 233–239.PubMedCrossRefGoogle Scholar
  24. 24.
    Lloyd, J., Brownson, C.,1Weedie, S., Charlton, J., and Edwards, Y. H.,1987, Genes Dev. 1: 594–602.Google Scholar
  25. 25.
    Martini, G., Toniola, D., Vulliamy, T, Luzzato, L., Dono, R., Viglietto, G., Paonessa, G., Durso, M., and Perisco, M., 1986, EMBO J. 5: 1849–1855.PubMedGoogle Scholar
  26. 26.
    Mode, A., Gustafsson, J.-A., Jansson, J.-O., Eden, S., and Isaksson, O., 1982, Endocrinology 111: 1692–1697.PubMedCrossRefGoogle Scholar
  27. 27.
    Mulvihill, E., LePenneo, J.-P., and Chambon, P, 1982, Cell 28: 621–632.PubMedCrossRefGoogle Scholar
  28. 28.
    Nakai, H., Byers, M. G., Venta, P. J., Tashian, R. E., and Shows, T. B., 1987, Cytogenet. Cell Genet. 44: 234–235.PubMedCrossRefGoogle Scholar
  29. 29.
    Norstedt, G., and Pahniter, R., 1984, Cell 36: 805–812.PubMedCrossRefGoogle Scholar
  30. 30.
    Pette, D., 1984, Med. Sci. Sports 16: 517–528.Google Scholar
  31. 31.
    Salmons, S., and Henriksson, J., 1981, Muscle Nerve 4: 94–105.PubMedCrossRefGoogle Scholar
  32. 32.
    Senke, M., Grundstrom, T, Matthes, H., Witzerith, M., Schatz, C., Wildeman, A., and Chambon, P, 1986, EMBO J. 5: 387–397.Google Scholar
  33. 33.
    Shani, M., Zevin-Sonkin, D., Saxel, O., Cannon, Y., Katcoff, D., Nudel, U., and Yaffe, D.,1981, Dey. Biol. 86: 483–492.Google Scholar
  34. 34.
    Shapiro, L., Venta, P, and Tashian, R., 1987, Mol. Cell. Biol. 7: 4589–4593.PubMedGoogle Scholar
  35. 35.
    Shies, A., Jeffery, S., Phillips, I., Shephard, E., Wilson, C., and Carter, N., 1983, Biochem. Biophys. Acta 760: 335–342.CrossRefGoogle Scholar
  36. 36.
    Tashian, R. E., 1989, BioEssays 10: 186–192.PubMedCrossRefGoogle Scholar
  37. 37.
    Tashian, R. E., and Hewett-Emmett, D. (eds.), 1984, Ann. N.Y. Acad. Sci. 249.Google Scholar
  38. 38.
    Weedie, S., and Edwards, Y., 1989, Biochem. Genet. 27: 17–30.CrossRefGoogle Scholar
  39. 39.
    Venta, P, Montgomery, J., Hewett-Emmett, D., Wiebauer, K., and Tashian, R., 1985, J. Biol. Chem. 260: 12130–12135.PubMedGoogle Scholar
  40. 40.
    Venta, P, Shows, T., Curtis, P, and làshian, R.,1983, Proc. Natl. Acad. Sci. USA 80: 4437–4440.Google Scholar
  41. 41.
    Wistrand, P, Carter, N., and Askmark, H., 1987, Comp. Biochem. Physiol. 86A: 177–184.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Yvonne H. Edwards
    • 1
  1. 1.MRC Human Biochemical Genetics Unit, The Galton LaboratoryUniversity College LondonLondonUK

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