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Structure and Expression of the Carbonic Anhydrase III Gene

  • Yvonne H. Edwards

Abstract

Carbonic anhydrase (CA) has evolved into at least six separate forms, CA I to CA VI (for reviews, see references 36 and 37). Structural comparisons at both the protein and DNA levels show that the CA gene family has expanded from a single ancestral gene by the process of duplication; this origin is further evidenced by chromosomal synteny of at least three of the CA genes. The close linkage of mouse CA1 and CA2 near the centromere of chromosome 3 was reported more than a decade ago.12 More recently, we have shown by linkage analysis and in situ hybridization that mouse CA3 maps to the same region.1 Similarly, the human CA1, CA2, and CA3 genes have been shown to be clustered on the long arm of chromosome 8 at g22.7,9,10,28 The probable presence of CA I, CA II, and CA III isoforms in birds and reptiles suggests that the duplicated CA genes have maintained linkage for more than 300 million years. It is not clear why this linkage has been retained and whether the chromosomal proximity of the CA genes plays any part in their widely diverse patterns of expression.

Keywords

Carbonic Anhydrase Human Carbonic Anhydrase Single Ancestral Gene eDNA Probe Mononucleate Myoblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Yvonne H. Edwards
    • 1
  1. 1.MRC Human Biochemical Genetics Unit, The Galton LaboratoryUniversity College LondonLondonUK

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