Expression of Carbonic Anhydrases I and II in Mouse Erythropoiesis
Carbonic anhydrase (CA) is the second most abundant protein in red blood cells, where it exists in two isozymic forms, CA I and CA II. CA I is found in a limited number of tissues besides red blood cells, including intestinal epithelium, vascular endothelium, corneal epithelium, and lens of the eye. CA II, though most abundant in red blood cells, is found in a wide variety of cells and tissues. The ratio of these two isozymes in red blood cells varies from species to species; the ratios of CA I to CA II are 6:1 in humans, 27:1 in orangutans, 2.6:1 in macaques, and 1:2 in mice. However, CA II is considerably more active than CA I; thus, the physiological significance of CA I is uncertain, since there exists CA I deficiency in red blood cells of macaques and humans with no observable effect.
KeywordsCarbonic Anhydrase Erythroid Differentiation Hypersensitive Site Uninduced Cell Carbonic Anhydrase Expression
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