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Afferent Nerve-Mediated Control of Gastric Mucosal Blood Flow and Protection

  • Peter Holzer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)

Abstract

The gastric mucosa is constantly exposed to chemical hazard, the threats being of both endogenous and exogenous origin. Most tissues would rapidly disintegrate if exposed to the concentrations of hydrochloric acid that bathe but do not harm the gastric surface epithelium. This is because a multitude of mechanisms constituting the gastric mucosal barrier (Davenport, 1972) prevent hydrogen ions from entering the tissues in quantities that would produce cell injury. Yet even a weakening of the barrier will usually not lead to any major lesion formation because emergency or protective mechanisms will take effect, limit the damage and promote repair of the injured tissue.

Keywords

Gastric Mucosa Sensory Neuron Mucosal Blood Flow Gastric Mucosal Damage Sensory Nerve Ending 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Peter Holzer
    • 1
    • 2
  1. 1.Center for Ulcer Research and Education, Veterans Administration Wadsworth Medical CenterUniversity of California at Los AngelesLos AngelesUSA
  2. 2.Department of Experimental and Clinical PharmacologyUniversity of GrazGrazAustria

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