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Gastric and Jejunal Ultrastructure in Capsaicin-Treated Rats with and without Experimental Ulcer

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Sensory Nerves and Neuropeptides in Gastroenterology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 298))

Abstract

In recent years considerable interest has been demonstrated in defining the role and interactions of sensory nerves and neuropeptides in the gastrointestinal tract, where such afferent nerves are present and where some identical peptides occur in endocrine cells and neuronal tissues. Capsaicin (8-methyl-N-va-nillyl-6-nonenamide), the irritant principle of the Capsicum genus peppers, has been proven to be a valuable pharmacologic probe of high but not absolute selectivity for its actions on primary afferent neurons in the gastrointestinal tract and elsewhere (Maggi and Meli, 1988). Exogenous administration of capsaicin to animals selectively damages sensory afferents in the gut in a manner dependent upon dose, age of animal, etc. The damage occurs in gastric neurons containing tachykinins and calcitonin gene-related peptide, in substance P-containing afferents in anorectal mucosa, and other neurons. In the nervous system of the rat, somatostatin, substance P, and other neuropeptides are also depleted by systemic capsaicin desensitization (Gamse et al., 1984; Sternini and Brecha, 1985; Skofitsch and Jacobowitz, 1985).

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Author information

Authors and Affiliations

  1. Department of Biomedical Sciences Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

    Carl J. Pfeiffer

  2. A. Menarini Pharmaceuticals, Pharmacology Department, Via Sette Santi 3, Florence, Italy

    Stefano Evangelista

Authors
  1. Carl J. Pfeiffer
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  2. Stefano Evangelista
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Editor information

Editors and Affiliations

  1. Flinders University of South Australia, Adelaide, Australia

    Marcello Costa

  2. University of Florence, Florence, Italy

    Calogero Surrenti

  3. Fondazione Internazionale Menarini, Florence, Italy

    Sergio Gorini

  4. A. Menarini Pharmaceuticals, Florence, Italy

    Carlo Alberto Maggi  & Alberto Meli  & 

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© 1991 Springer Science+Business Media New York

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Pfeiffer, C.J., Evangelista, S. (1991). Gastric and Jejunal Ultrastructure in Capsaicin-Treated Rats with and without Experimental Ulcer. In: Costa, M., Surrenti, C., Gorini, S., Maggi, C.A., Meli, A. (eds) Sensory Nerves and Neuropeptides in Gastroenterology. Advances in Experimental Medicine and Biology, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0744-8_8

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  • DOI: https://doi.org/10.1007/978-1-4899-0744-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0746-2

  • Online ISBN: 978-1-4899-0744-8

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