Evolutionary Aspects in the Peripheral Peptidergic Signals: CRF-Like Peptides and Modulation of G.I. Functions
In studies of peptide structure-function relationships evolutionary changes are important tools. A study of the differences between species helps one to understand the importance of functional and receptor addressing domains in the sequence as well as of the side chains of some amino acid residues. Intra-and interpeptide relationships reveal the presence of preserved sequences and relate many peptides in families. In biologically active peptides, evolutionary changes may reflect additional complexity since these peptides interact with receptors and therefore participate in a system of co-evolving protein structures and inter-cell signaling. In evolutionary studies of the most basic properties of a peptide family, it is essential to include variants that differ widely from one another. This is because in closely related forms, differences are often trivial or random, and therefore of little general value. To enable one to draw conclusions about fundamental properties conserved during evolution an appropriate choice would involve peptides that are present in phylogenetically distant species.
KeywordsGastric Emptying Gastric Acid Secretion Sensory Terminal Fish Tail Vagal Afferent Pathway
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