Evolutionary Aspects in the Peripheral Peptidergic Signals: CRF-Like Peptides and Modulation of G.I. Functions

  • Giovanna Improta
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)


In studies of peptide structure-function relationships evolutionary changes are important tools. A study of the differences between species helps one to understand the importance of functional and receptor addressing domains in the sequence as well as of the side chains of some amino acid residues. Intra-and interpeptide relationships reveal the presence of preserved sequences and relate many peptides in families. In biologically active peptides, evolutionary changes may reflect additional complexity since these peptides interact with receptors and therefore participate in a system of co-evolving protein structures and inter-cell signaling. In evolutionary studies of the most basic properties of a peptide family, it is essential to include variants that differ widely from one another. This is because in closely related forms, differences are often trivial or random, and therefore of little general value. To enable one to draw conclusions about fundamental properties conserved during evolution an appropriate choice would involve peptides that are present in phylogenetically distant species.


Gastric Emptying Gastric Acid Secretion Sensory Terminal Fish Tail Vagal Afferent Pathway 
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  1. Bern, H.A., Pearson, D., Larson, B.A., Nishioka, R.S., 1985, Neurohormone from fish tails: the caudal neurosecretory system, Recent Progress in Hormone Research, 41:533.PubMedGoogle Scholar
  2. Broccardo, M., Improta, G., Melchiorri, P., 1982, Effect of Sauvagine on gastric emptying in conscious rats, Eur. J. Pharmacol., 85:111.PubMedCrossRefGoogle Scholar
  3. Brown, M.R., Fisher, A.L., Spiess, J., Rivier, J., Rivier, C., Vale, W., 1982, Comparison of the biological actions of cor-ticotropin-releasing factor and sauvagine, Regul. Peptides, 4:107.CrossRefGoogle Scholar
  4. Erspamer, V., Falconieri Erspamer, G., Improta, G., Negri, L., de Castiglione, R., 1980, Sauvagine, a new polypeptide from Phyllomedusa sauvagei skin. Occurrence in various Phyllomedusa species and pharmacological actions on rat blood pressure and diuresis, Naunyn-Schmiedeberg’s Arch. Pharmacol., 312:265.CrossRefGoogle Scholar
  5. Erspamer, V., Melchiorri, P., Broccardo, M., Falconieri Erspamer, G., Falaschi, P., Improta, G., Negri, L., Renda, T., 1981, The brain-gut-skin triangle: new peptides, Peptides, 2:7.PubMedCrossRefGoogle Scholar
  6. Improta, G., Broccardo, M., 1988, Sauvagine: effects on gastric acid secretion in rats, Peptides, 9:843.PubMedCrossRefGoogle Scholar
  7. Konturek, S.J., Bilski, J., Pawlik, W., Thor, P., Czarnobiliski, K., Szoke, B., Schally, A.V., 1985, Gastrointestinal secretory, motor and circulatory effects of corticotropin releasing factor (CRF), Life Sciences, 37:1231.PubMedCrossRefGoogle Scholar
  8. Lederis, K., Fryer, J., Rivier, J., MacCannell, K.L., Kobayashi, Y., Woo, N., Wong, K.L., 1985, Neurohormones from fish tails: actions of urotensin I in mammals and fishes, Recent Progress in Hormone Research, 41:553.PubMedGoogle Scholar
  9. Lederis, K., Fryer, J.N., Yulis, C.R., 1985, The fish neuropeptide urotensin I: its physiology and pharmacology, Peptides, 6:353.PubMedCrossRefGoogle Scholar
  10. Lederis, K., Ko, D., Rivier, J., Melchiorri, P., Negri, L., 1987, Specificity and sensitivity of antisera produced a-gainst non-coniugated urotensin I and related peptides, Proc. West. Pharmacol. Soc., 30:187.PubMedGoogle Scholar
  11. Lenz, H.J., Fisher, L.A., Vale, W.W., Brown, M.R., 1985, Corticotropin-releasing factor, Sauvagine and Urotensin I: effects on blood flow, Am. J. Physiol., 249:R85.Google Scholar
  12. Lenz, H.J., Klapdor, R., Hester, S.E., Webb, V.J., Galyean, R.F., Rivier, J.E., Brown, M.R., 1986, Inhibition of gastric acid secretion by brain peptides in the dog, Gastroenterology, 91:905.PubMedGoogle Scholar
  13. Melchiorri, P., Negri, L., 1981, Action of sauvagine on the mesenteric vascular bed of the dog, Regul. Peptides, 2:1.CrossRefGoogle Scholar
  14. Melchiorri, P., Negri, L., Erspamer, V., 1982, Effects of sauvagine on release of prolactin, adrenocorticotropin, beta-endorphin and corticosterone in rats, in: “Neuroendocrinology of Vasopressin Corticoliberin and Opiomelanocortins,” A.J. Baerschi and J.J. Dreifuss, eds., Academic Press, London.Google Scholar
  15. Minniti, F., Donato, A., D’este, L., Renda, T., 1989, Sauvagine/ urotensin I-like immunoreactivity in the caudal and neurosecretory system of a sea water fish Diplodus sargus L. in normal and hyposmotic milieu, Peptides, 10:383.PubMedCrossRefGoogle Scholar
  16. Montecucchi, P.C., Henschen, A., Erspamer, V., 1979, Structure of sauvagine, a vasoactive peptide from the skin of a frog, Hoppr-Seyler’s Z. Physiol. Chem., 360:1178.Google Scholar
  17. Negri, L., Noviello, L., Noviello V., 1985, Effects of sauvagine, urotensin I and CRF on food intake in rats, Peptides, 6:59.CrossRefGoogle Scholar
  18. Taché, Y., Goto, Y., Gunion, M.W., Vale, W., Brown, M., 1983, Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor, Science, 222:935.PubMedCrossRefGoogle Scholar
  19. Taché, Y., Goto, Y., Gunion, M., Rivier, J., Debas, H., 1984, Inhibition of gastric acid secretion in rats and in dogs by corticotropin-releasing factor, Gastroenterology, 86:281.PubMedGoogle Scholar
  20. Taché, Y., Maeda-Hagiwara, M., Turkelson, C.M., 1987, Central nervous system action of corticotropin releasing factor to inhibit gastric emptying in rats, Am. J. Physiol., 253:G241.Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Giovanna Improta
    • 1
  1. 1.Institute of PharmacologyUniversity “La Sapienza”RomeItaly

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