Activation of Sensory Nerves by Kinins: Pharmacologic Tools for Studying Kinin Receptors

  • D. Regoli
  • N.-E. Rhaleb
  • N. Rouissi
  • C. Tousignant
  • D. Jukic
  • C. Drapeau
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)


Bradykinin and kallidin are released in blood and tissues by several stimuli and produce a variety of local effects by acting as autacoids. Some of these effects appear to be initiated by stimulation of afferent fibers and produce tissue responses of reflex nature. Indeed, bradykinin has been shown to be the most active endogenous agent to produce pain sensation when applied to blister base in man (1, 2, 3): this peptide has also been found to activate nociceptive responses in laboratory animals (Table 1), among others the writhing syndrome in the mouse (4, 5) the vocalization response in the dog (6), the reflex head flexion reaction in the rat (7, 8) and other painful responses (see Garcia-Leme (9) and Clark (50), for reviews). In other in vivo assays in the dog, the cat and the rat, bradykinin has been used to stimulate sensory fibers and activate cardiovascular reflexes. Thus, Lombardi et al. (10) and Malliani (11) have applied bradykinin in the coronary arteries of anesthetized cats to activate reflex responses of the sympathetic and vagal cardiac sensory nerves. They have observed an increase of the left ventricular and of the systemic pressures, together with a significant increase in the sympathetic efferent impulses.


Rabbit Aorta Kinin Receptor Iris Sphincter Paracrine Hormone Vocalization Response 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • D. Regoli
    • 1
  • N.-E. Rhaleb
    • 1
  • N. Rouissi
    • 1
  • C. Tousignant
    • 1
  • D. Jukic
    • 1
  • C. Drapeau
    • 1
  1. 1.Department of Pharmacology, Medical SchoolUniversity of SherbrookeSherbrookeCanada

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