Peptides and their Receptors on Afferent Neurons to the Upper Gastrointestinal Tract

  • G. J. Dockray
  • E. R. Forster
  • S. M. Louis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)


The two morphological divisions of the afferent innervation of the upper gastrointestinal tract, the vagal and splanchnic nerves, are distinguishable in functional and in neurochemical terms. It has been known since the early part of the century that the vagal pathway mediates physiological reflexes involved in the normal control of gastric motility and secretion, and that the splanchnic pathway mediates the effects of noxious stimulation of the gut (Hertz, 1911). Peptides are involved in these functions in two ways — as mediators of some of the effects of nerve stimulation, and as modulators of afferent discharge by acting at peptide receptors expressed on afferent nerve fibres (Dockray, 1988). Splanchnic afferents are a rich source of neuropeptides and provide a good illustration of how peptides might mediate the function of some visceral afferents, while vagal fibres express receptors for several peptides and so illustrate modulatory functions. The present account will deal with the physiological significance of these actions.


Gastric Emptying Calcitonin Gene Related Peptide Vasoactive Intestinal Polypeptide Delay Gastric Emptying Afferent Innervation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • G. J. Dockray
    • 1
  • E. R. Forster
    • 1
  • S. M. Louis
    • 1
  1. 1.MRC Secretory Control Research Group, Physiological LaboratoryUniversity of LiverpoolLiverpoolEngland

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