2-Deoxy-D-Glucose (2-DG)-Induced Increase in Gastric Acid Secretion is Impaired in Capsaicin-Pretreated Rats

  • S. Evangelista
  • P. Santicioli
  • C. A. Maggi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)


This study investigated the increase in gastric acid secretion induced by intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg’1), insulin (5 U kg-1) or by electrical stimulation of the vagus nerve (1 mA, 1 ms, 3 Hz) in urethane-anesthe-tized rats pretreated when newborn with either capsaicin or the vehicle.

The secretory response to 2-DG was substantially reduced in the capsaicin pretreated rats, while those induced by electrical vagal stimulation or insulin were unaffected.

These findings suggest that capsaicin-sensitive fibers are involved in the afferent branch of the reflex response activated by 2-DG to stimulate gastric acid secretion.


Vagus Nerve Gastric Acid Secretion Vagal Stimulation Mucosal Blood Flow Gastric Mucosal Blood Flow 
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  1. Alfoldi, P., Obal, F., Toth, E., and Hideg, J., 1986, Capsaicin pretreatment reduces the gastric acid secretion elicited by histamine but does not affect the responses to carbachol and pentagastrin, Eur. J. Pharmacol., 123:321.PubMedCrossRefGoogle Scholar
  2. Amann, R., Lembeck, F., 1986, Capsaicin sensitive afferent neurons from peripheral glucose receptors mediate the insulin-induced increase in adrenaline secretion, Naunyn-Schmiedeberg’s Arch. Pharmacol., 334:71.CrossRefGoogle Scholar
  3. Colin-Jones, D.G., and Himsworth, R.L., 1970, Location of the chemoceptor controlling gastric acid secretion during hypoglycemia, J. Physiol., 206:397.PubMedGoogle Scholar
  4. Dugani, A.M., and Glavin, G.B., 1986, Capsaicin effects on stress pathology and gastric acid secretion in rats, Life Sci., 39:1531.PubMedCrossRefGoogle Scholar
  5. Evangelista, S., Santicioli, P., Maggi, CA., and Meli, A., 1989, Increase in gastric secretion induced by 2-deoxy-D-glucose is impaired in capsaicin pretreated rats, Br. J. Pharmacol., 98:35.PubMedCrossRefGoogle Scholar
  6. Ghosh, M.N., and Schild, H.O., 1958, Continuous recording of acid secretion in the rat, Br. J. Pharmacol., 13:54.Google Scholar
  7. Hirshowitz, B.I., and Sachs, G., 1965, Vagal gastric secretory stimulation by 2-deoxy-D-glucose, Am. J. Physiol., 209:452.Google Scholar
  8. Lippe, I. Th., Pabst, M.A., and Holzer, P., 1989, Intragastric capsaicin enhances rat gastric acid elimination and mucosal blood flow by afferent nerve stimulation, Br. J. Pharmacol., 96:91.PubMedCrossRefGoogle Scholar
  9. Maggi, C.A., and Meli, A., 1988, The sensory-efferent function of capsaicin-sensitive sensory neurons, Gen. Pharmacol., 19:1.PubMedCrossRefGoogle Scholar
  10. Raybould, H.E., and Taché, Y., 1989, Capsaicin-sensitive vagal afferent fibers and stimulation of gastric acid secretion in anesthetized rat, Eur. J. Pharmacol., 167:237.PubMedCrossRefGoogle Scholar
  11. Ritter, S., and Dinh, T.T., 1988, Capsaicin-induced neuronal degeneration: silver impregnation of cell bodies, axons and terminals in the central nervous system of the adult rat, J. Comp. Neurol., 271:79.PubMedCrossRefGoogle Scholar
  12. Sternini, C., Reeve, J.R., and Brecha, N., 1987, Distribution and characterization of calcitonin gene-related peptide immuno-reactivity in the digestive system of normal and capsaicin-treated rats, Gastroenterology, 93:852.PubMedGoogle Scholar
  13. Taché, Y., 1987, Central nervous system regulation of gastric acid secretion, in: “Physiology of the Gastrointestinal Tract”, Vol. 2 (Second edition), L.R. Johnson, ed., Raven Press, New York.Google Scholar
  14. Thieflin, G., Raybould, H.E., Leung, F.W., Taché, Y., and Guth, P.H., 1989, Role of capsaicin-sensitive vagal afferent fibers in increased gastric mucosal blood flow induced by electrical vagal stimulation in the rat, Gastroenterology, 96:A509.Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • S. Evangelista
    • 1
  • P. Santicioli
    • 1
  • C. A. Maggi
    • 1
  1. 1.Pharmacology DepartmentMenarini PharmaceuticalsFlorenceItaly

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