2-Deoxy-D-Glucose (2-DG)-Induced Increase in Gastric Acid Secretion is Impaired in Capsaicin-Pretreated Rats
This study investigated the increase in gastric acid secretion induced by intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg’1), insulin (5 U kg-1) or by electrical stimulation of the vagus nerve (1 mA, 1 ms, 3 Hz) in urethane-anesthe-tized rats pretreated when newborn with either capsaicin or the vehicle.
The secretory response to 2-DG was substantially reduced in the capsaicin pretreated rats, while those induced by electrical vagal stimulation or insulin were unaffected.
These findings suggest that capsaicin-sensitive fibers are involved in the afferent branch of the reflex response activated by 2-DG to stimulate gastric acid secretion.
KeywordsVagus Nerve Gastric Acid Secretion Vagal Stimulation Mucosal Blood Flow Gastric Mucosal Blood Flow
Unable to display preview. Download preview PDF.
- Ghosh, M.N., and Schild, H.O., 1958, Continuous recording of acid secretion in the rat, Br. J. Pharmacol., 13:54.Google Scholar
- Hirshowitz, B.I., and Sachs, G., 1965, Vagal gastric secretory stimulation by 2-deoxy-D-glucose, Am. J. Physiol., 209:452.Google Scholar
- Taché, Y., 1987, Central nervous system regulation of gastric acid secretion, in: “Physiology of the Gastrointestinal Tract”, Vol. 2 (Second edition), L.R. Johnson, ed., Raven Press, New York.Google Scholar
- Thieflin, G., Raybould, H.E., Leung, F.W., Taché, Y., and Guth, P.H., 1989, Role of capsaicin-sensitive vagal afferent fibers in increased gastric mucosal blood flow induced by electrical vagal stimulation in the rat, Gastroenterology, 96:A509.Google Scholar