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2-Deoxy-D-Glucose (2-DG)-Induced Increase in Gastric Acid Secretion is Impaired in Capsaicin-Pretreated Rats

  • S. Evangelista
  • P. Santicioli
  • C. A. Maggi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)

Summary

This study investigated the increase in gastric acid secretion induced by intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg’1), insulin (5 U kg-1) or by electrical stimulation of the vagus nerve (1 mA, 1 ms, 3 Hz) in urethane-anesthe-tized rats pretreated when newborn with either capsaicin or the vehicle.

The secretory response to 2-DG was substantially reduced in the capsaicin pretreated rats, while those induced by electrical vagal stimulation or insulin were unaffected.

These findings suggest that capsaicin-sensitive fibers are involved in the afferent branch of the reflex response activated by 2-DG to stimulate gastric acid secretion.

Keywords

Vagus Nerve Gastric Acid Secretion Vagal Stimulation Mucosal Blood Flow Gastric Mucosal Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • S. Evangelista
    • 1
  • P. Santicioli
    • 1
  • C. A. Maggi
    • 1
  1. 1.Pharmacology DepartmentMenarini PharmaceuticalsFlorenceItaly

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