Sensory Denervation with Capsaicin Reduces the Liver Collagen Deposition Induced by Common Bile Duct Obstruction in Rats

  • Alessandro Casini
  • Irmgard Th. Lippe
  • Stefano Evangelista
  • Pierangelo Geppetti
  • Paolo Santicioli
  • Carmelo Urso
  • Carlo Alberto Maggi
  • Calogero Surrenti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)

Abstract

Hepatic fibrosis indicates an increased deposition of the normal components of connective tissue in the liver, associated with an altered balance between synthesis and degradation of collagen (Anthony et al., 1978; Hann et al., 1985). This widespread alteration of the liver represents an important stage in the progression of chronic liver disease to cirrhosis (Conn, 1982; Rappaport et al., 1983).

Keywords

Common Bile Duct Bile Duct Ligation Primary Sensory Neuron Bile Duct Obstruction Common Bile Duct Ligation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anthony, P.P., Ishak, K.G., Nayak, N.C., 1978, The morphology of cirrhosis, J. Clin. Pathol., 395:414.Google Scholar
  2. Buck, S.H., Burks, T.F., 1986, The neuropharmacology of capsaicin. Review of some recent observations, Pharmac. Rev., 38:179.Google Scholar
  3. Casini, A., Martini, F., Nieri, S., Ramarli, D., Franconi, F., Surrenti C., 1982, High performance liquid chromatographic determination of hydroxyprolin after derivatization with 4-dimethyl-aminoazobenzene-4′-sulphonyl chloride, J. Chromatogr., 249:187.PubMedCrossRefGoogle Scholar
  4. Conn, O.H., 1982, Cirrhosis, in: “Diseases of the Liver”, Lippincott, Philadelphia.Google Scholar
  5. Gamse, R., 1982, Capsaicin and nociception in the rat and mouse, Naunyn Schiedeberg’s Arch. Pharmac., 320:205.CrossRefGoogle Scholar
  6. Geppetti, P., Maggi, C.A., Zecchi-Orlandini, S., Santicoli P., Meli, A., Frilli, S., Spillantini, M.G., and Amenta, F., 1987, Substance P-like immunoreactivity in capsaicin-sensitive structures of the rat thymus, Regul. Peptides, 18:321.CrossRefGoogle Scholar
  7. Goheler, L.E., Sternini, C., Brecha, N.C., 1988, Calcitonin gene-related peptide immunoreactivity in the biliary pathway and liver of the guinea-pig: distribution and colocalization with substance P, Cell Tissue Res., 253:145.Google Scholar
  8. Hahn, E.G., Schuppan, D., 1985, Ethanol and fibrogenesis in the liver, in: “Alcohol Related Diseases in Gastroenterology”, H.K. Seitz and B. Kommereil, eds., Springer-Verlag, Berlin and Heidelberg.Google Scholar
  9. Holzer, P., 1988, Local effector functions of capsaicin-sensitive sensory nerve ending: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides, Neuroscience, 24:739.PubMedCrossRefGoogle Scholar
  10. Jalkanen, M., Tammi, M., Vihersaari, T., 1980, A rapid assay to measure collagen synthesis in cell cultures, J. Biochem. Biophys. Methods, 2:331.PubMedCrossRefGoogle Scholar
  11. Jamall, I.S., Finelli, V.M., Que Hee, S.S., 1981, A sample method to determine nanogram levels of 4-hydroxyproline in biological tissues, Anal. Biochem., 112:70.PubMedCrossRefGoogle Scholar
  12. Jancsó, G., Kiraly, E., Such, G., Joo, F., Nagy, A., 1987, Neurotoxic effect of capsaicin in mammals, Acta Physiol. Hung., 69:295.PubMedGoogle Scholar
  13. Jancsó, G., Kiraly, E., Joo, F., Such, G., Nagy, A., 1985, Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in adult rats, Neurosci. Letters, 59:209.CrossRefGoogle Scholar
  14. Kjartansson, J., Dalsgaard, C.J., 1987, Calcitonin gene-related peptide increases survival of a musculocutaneous critical flap in the rat, Eur. J. Pharmacol., 142:355.PubMedCrossRefGoogle Scholar
  15. Kjartansson, J., Dalsgaard, C.J., 1987, Decreased survival of experimental critical flaps in rats after sensory denervation with capsaicin, Plast. Reconstr. Surg., 79:218.PubMedCrossRefGoogle Scholar
  16. Kountouras, J., Billing, B.H., Scheuer, P.J., 1984, Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat, Br. J. Exp. Path., 64:305.Google Scholar
  17. Maggi, C.A., Meli, A., 1988, The sensory-efferent function of capsaicin-sensitive sensory neurons, Gen. Pharmac, 19:1.CrossRefGoogle Scholar
  18. Maggi, C.A., Borsini, F., Santicioli, P., Geppetti, P., Abelli, L., Evangelista, S., Manzini, S., Theodorsson-Norheim, E., Somma, V., Amenta, F., Bacciarelli C., and Meli, A., 1987a, Cutaneous lesions in capsaicin-pretreated rats. A trophic role of capsaicin-sensitive afferents? Naunyn Schmiedeberg’s Arch. Pharmacol., 336:538.Google Scholar
  19. Maggi, C.A., Santicioli, P., Geppetti, P., Furio, M., Frilli, S., Conte, B., Fanciullacci, M., Giuliani, S., and Meli, A., 1987b, The contribution of capsaicin-sensitive innervation to activation of the spinal vescico-vescical reflex in rats: relationship between substance P levels in the urinary bladder and the sensory-efferent function of capsaicin-sensitive sensory neurons, Brain Res., 415:1.PubMedCrossRefGoogle Scholar
  20. Nilsson, J., Von Euler, A.M., Dalsgaard, C.J., 1985, Stimulation of connective tissue cell growth by substance P and substance K, Nature, 315:61.PubMedCrossRefGoogle Scholar
  21. Rappaport, A.M., Mac Phee P.J., Fischer, M.M., Phillips, M.J., 1983, The scarring of the liver acini (cirrhosis), Virchows Arch., 402:107.CrossRefGoogle Scholar
  22. Ritter, S., and Dinh, T.T., 1988, Capsaicin-induced neuronal degeneration: silver impregnation of cell bodies, axons and terminals in the central nervous system of the adult rat, J. Comp. Neurol., 271:79.PubMedCrossRefGoogle Scholar
  23. Sasaki, Y., Kamada, T., Hayashi, N, 1984, Immunohistochemical distribution of glucagon, substance P and vasoactive intestinal polipeptide in hepatic vasculature of the rat, Hepatology, 6: 1184.CrossRefGoogle Scholar
  24. Sasaki, Y., Hayashi, N., Kasahara, A., 1986, Calcitonin gene-related peptide in the hepatic and splanchnic vascular systems of the rat, Hepatology, 6:676.PubMedCrossRefGoogle Scholar
  25. Senapati, A., Anand, P., McGregor, G..P., Ghatei, M.A., Thompson, R.P.H., Bloom, S.R., 1986, Depletion of neuropeptides during wound healing in rat skin, Neurosci. Letters, 71:101.CrossRefGoogle Scholar
  26. Szolcsányi J., 1984, Capsaicin-sensitive chemoceptive neural system with dual sensory-efferent function, in: “Antidromic Vasodilatation and Neurogenic Inflammation”, L.A. Chahl, J. Szolcsányi and F. Lembeck, eds., Akademiai Kiado, Budapest.Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Alessandro Casini
    • 1
  • Irmgard Th. Lippe
    • 2
  • Stefano Evangelista
    • 3
  • Pierangelo Geppetti
    • 4
  • Paolo Santicioli
    • 3
  • Carmelo Urso
    • 5
  • Carlo Alberto Maggi
    • 3
  • Calogero Surrenti
    • 1
  1. 1.Department of PathophysiologyGastroenterology UnitFlorenceItaly
  2. 2.Department of Experimental and Clinical PharmacologyUniversity of GrazGrazAustria
  3. 3.Menarini PharmaceuticalsUniversity of Florence and Department of PharmacologyFlorenceItaly
  4. 4.Institute of Internal Medicine and Clinical PharmacologyFlorenceItaly
  5. 5.Institute of PathologyFlorenceItaly

Personalised recommendations