Tachykinin Receptors in the Longitudinal and Circular Muscle of the Human Ileum
Tachykinins are a family of peptides which share the common C-terminal sequence Phe — x — Gly — Leu — Met NH2. Ample evidence, based on pharmacological, physiological, anatomical and neurochemical bases indicates that tachykinins, such as substance P (SP), play a physiological role as excitatory transmitters in the guinea-pig ileum (Costa et al., 1985; see also Barthó & Holzer 1985 for review). In the guinea-pig intestine, SP and other tachykinins, such as neurokinin A (NKA) are mainly stored in certain intrinsic neurons which are thought to play a role as final effectors of atropine-resistant peristalsis (Barthó and Holzer 1985 for review).
KeywordsLongitudinal Muscle Circular Muscle Electrical Field Stimulation Human Gastrointestinal Tract Tachykinin Receptor
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