Tachykinin Receptors in the Longitudinal and Circular Muscle of the Human Ileum

  • Sandro Giuliani
  • Carlo Alberto Maggi
  • Riccardo Patacchini
  • Paolo Santicioli
  • Damiano Turini
  • Gabriele Barbanti
  • Paolo Rovero
  • Antonio Giachetti
  • Alberto Meli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)

Abstract

Tachykinins are a family of peptides which share the common C-terminal sequence Phe — x — Gly — Leu — Met NH2. Ample evidence, based on pharmacological, physiological, anatomical and neurochemical bases indicates that tachykinins, such as substance P (SP), play a physiological role as excitatory transmitters in the guinea-pig ileum (Costa et al., 1985; see also Barthó & Holzer 1985 for review). In the guinea-pig intestine, SP and other tachykinins, such as neurokinin A (NKA) are mainly stored in certain intrinsic neurons which are thought to play a role as final effectors of atropine-resistant peristalsis (Barthó and Holzer 1985 for review).

Keywords

Longitudinal Muscle Circular Muscle Electrical Field Stimulation Human Gastrointestinal Tract Tachykinin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Sandro Giuliani
    • 1
  • Carlo Alberto Maggi
    • 1
  • Riccardo Patacchini
    • 1
  • Paolo Santicioli
    • 1
  • Damiano Turini
    • 2
  • Gabriele Barbanti
    • 2
  • Paolo Rovero
    • 3
  • Antonio Giachetti
    • 1
  • Alberto Meli
    • 1
  1. 1.Pharmacology Department, Smooth Muscle Division, Research LaboratoriesA. Menarini PharmaceuticalsFlorenceItaly
  2. 2.Dept. of Surgical Pathology and Urologic ClinicUniversity of FerraraItaly
  3. 3.Chemistry DepartmentMenarini PharmaceuticalsFlorenceItaly

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