Central and Peripheral Actions of Calcitonin Gene-Related Peptide on Gastric Secretory and Motor Function

  • Yvette Taché
  • Helen Raybould
  • Jen Yu Wei
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)


Calcitonin gene related peptide (CGRP) was one of the first examples of a biologically active peptide to be identified by recombinant DNA and molecular biological approach (Rosenfeld et al., 1983; Amara et al., 1985). It was also the first demonstration of tissue-specific alternative processing of a gene. In 1983, Rosenfeld et al. initially reported that the RNA transcript from the calcitonin gene is processed in rat central and peripheral neural tissues to a mRNA encoding the precursor to a previously unknown 37-residue peptide called CGRP or α-CGRP (Rosenfeld et al., 1983). In thyroidal cells, the calcitonin gene generates a mRNA which encodes a calcitonin precursor protein expressing the calcium-regulating hormone, calcitonin (Rosenfeld et al., 1983). Subsequently, both intra- and interspecies variants have been discovered. A second calcitonin gene generating a mRNA expressing β-CGRP or CGRP II was identified in rats (Amara et al., 1985). Rat β and α forms differ in only one amino acid residue at position 35. The same mechanism of specific alternate RNA processing was described in human tissue.


Acid Secretion Gastric Acid Secretion Calcitonin Gene Related Peptide Gastric Mucosal Blood Flow Dorsal Vagal Complex 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Yvette Taché
    • 1
  • Helen Raybould
    • 1
  • Jen Yu Wei
    • 1
  1. 1.Center for Ulcer Research and Education, VA Wadsworth Medical CenterDepartment of Medicine and Brain Research Institute UCLALos AngelesUSA

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