Relationship between Sensory Neuropeptides and other Local Vasoactive Mediators in Modulating Gastric Mucosal Integrity
The local release of sensory neuropeptides such as substance P and calcitonin gene-related factor (CGRP) from primary afferent neurones is considered to play a protective function in the gastric mucosa (see Holzer, 1988). Evidence for such a role is based predominantly on the findings in the rat that capsaicin pretreatment, which induces functional derangement of primary sensory neurones, substantially augments the gastric mucosal injury induced by a number of procedures including pylorus ligation and acid distension (Szolcsányi and Barthó, 1981) and administration of ulcerogens including ethanol and indomethacin (Holzer and Sarnetz, 1986; Esplugues and Whittle, 1990). Furthermore, acute exposure of the gastric mucosa to intraluminal capsaicin, which is considered to cause an initial stimulation of these afferent neurons and hence induce the release of sensory neuropeptides, has been shown to inhibit the mucosal damage induced by ethanol (Holzer and Lippe, 1988).
KeywordsNitric Oxide Gastric Mucosa Mucosal Injury Mucosal Blood Flow Gastric Damage
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