Opioid-Sensitive Peripheral Neuronal Activity in the Modulation of Gastric Mucosal Injury

  • J. V. Esplugues
  • B. J. R. Whittle
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)


There is growing evidence that capsaicin-sensitive afferent neurones participate in the protective mechanisms of the gastric mucosa against damage. Animals pretreated systemically with capsaicin, at doses that lead to the ablation of capsaicin-sensitive afferent neurons, show an increase in the level of macro-scopically apparent mucosal damage in different experimental models of ulceration (Szolcsányi and Barthó, 1981; Holzer and Sametz, 1986). Furthermore, acute stimulation with capsaicin of afferent nerve endings located in the gastric mucosa protects against different ulcerogenic mechanisms (Szolcsányi and Barthó, 1981; Holzer and Lippe, 1988; Holzer et al., 1989).


Gastric Mucosa Mucosal Damage Gastric Damage Gastric Mucosal Injury Gastric Mucosal Damage 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • J. V. Esplugues
    • 1
  • B. J. R. Whittle
    • 2
  1. 1.Departments of PharmacologyUniversity of ValenciaSpain
  2. 2.Wellcome Research LaboratoriesBeckenham, KentUK

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