Decrease of Duodenal Calcitonin Gene-Related Peptide- and Substance P-Like Immunoreactivity in Rat Duodenal Ulcers

  • Daniela Renzi
  • Stefano Evangelista
  • Paola Mantellini
  • Calogero Surrenti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)

Summary

We have investigated the endogenous levels of duodenal calcitonin gene-related peptide- (CGRP) and Substance P- (SP) like immunoreactivity (li) following the induction of duodenal ulcers in rats.

Using three duodenal ulcerogens, namely cysteamine, dulcero-zine or mepirizole given in a single oral dose, a decrease of duodenal CGRP-li and SP-li was observed. Time-relationship studies of this phenomenon show that CGRP-li and SP-li were decreased concomitantly to the formation of gastroduodenal ulcers after the administration of cysteamine (900 mg/kg p.o.).

Pretreatment with the selective sensory neurotoxin capsaicin induced CGPR-li decrease in the duodenum, which was not further decreased by an ulcerogenic dose of cysteamine, indicating that cysteamine induced a release of CGRP-li of capsaicin-sensitive origin. Otherwise duodenal SP-li was not sensitive to capsaicin pretreatment and its duodenal content decreased by cysteamine originates from an intrinsic source.

Our observations indicate that CGRP and SP may play an important local role in duodenal ulcerogenesis.

Keywords

Duodenal Ulcer Gastric Acid Secretion Vagal Nerve Stimulation Afferent Nerve Ending Gastric Acid Hypersecretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Daniela Renzi
    • 1
  • Stefano Evangelista
    • 2
  • Paola Mantellini
    • 1
  • Calogero Surrenti
    • 1
  1. 1.Gastroenterology Unit, Department of PathophysiologyUniversity of FlorenceFirenzeItaly
  2. 2.Pharmacology DepartmentMenarini PharmaceuticalsFirenzeItaly

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