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Vagal Afferent Innervation and Regulation of Gastric Function

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Sensory Nerves and Neuropeptides in Gastroenterology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 298))

Abstract

It has been recognized since the beginning of the century that many gastric functions are independent of the extrinsic nervous innervation but can be modulated through these nerves by mechanisms involving afferent fibers. The visceral afferent innervation may regulate gastric function in at least two ways: first, by initiating reflexes mediated through the CNS, vago-vagal reflexes and secondly, producing changes in function through local effector mechanisms. In the following article, experimental evidence will be presented to suggest that vagal afferents regulate several gastric functions, including the gastric phase of acid secretion and mucosal blood flow, the central modulation of vago-vagal reflexes and postprandial gastric motor function.

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References

  • Ainsworth, A., Hall, P., Wall, P.D., Allt, G., MacKenzie, M.L., Gibson, S., and Polak, J.M., 1981, Effects of capsaicin applied locally to adult peripheral nerve. II. Anatomy and enzyme and peptide chemistry of peripheral nerve and spinal cord, Pain, 11:379.

    Article  PubMed  CAS  Google Scholar 

  • Alfoldi, P., Obal, F., Toth, E., and Hideg, J., 1986, Capsaicin pretreatment reduces the gastric acid secretion elicited by histamine but does not affect the responses to carbachol and pentagastrin, Europ. J. Pharmacol., 123:321.

    Article  CAS  Google Scholar 

  • Azpiroz, F., and Malagelada, J.R., 1986, Vagally mediated gastric relaxation induced by intestinal nutrients in the dog, Am. J. Physiol., 215:G727.

    Google Scholar 

  • Bauerfeind, P., Hof, R., Hof, A., Cucula, M., Siegrist, S., von Ritter, C.H., Fischer, J.A., and Blum, A.L., 1989, Effects of hCGRP I and II on gastric blood flow and acid secretion in anesthetized rabbits, Am. J. Physiol., 256:G145.

    Google Scholar 

  • Buck, S.H., and Burks, T.F., 1986, The neuropharmacology of capsaicin: a review of some recent observations, Pharmacol. Rev., 38:179.

    PubMed  CAS  Google Scholar 

  • Cottrell, D.F., and Iggo, A., 1986, The responses of duodenal tension receptors in sheep to pentagastrin, cholecystokinin and some other drugs, J. Physiol., 354:477.

    Google Scholar 

  • Davison, J.S., and Clarke, G.D., 1988, Mechanical properties and sensitivity to CCK of vagal gastric slowly adapting mechano-receptor, Am. J. Physiol., 255:G55.

    Google Scholar 

  • Debas, H.T., 1987, Peripheral regulation of gastric acid secretion, in: “Physiology of the Gastrointestinal Tract,” L.R. Johnson, ed., Raven Press, New York.

    Google Scholar 

  • Debas, H.T., Konturek, S.J., Walsh, J.H., and Grossman, M.I., 1974, Proof of a pyloro-oxyntic reflex for stimulation of acid secretion, Gastroenterology, 66:526.

    PubMed  CAS  Google Scholar 

  • Debas, H.T., Farooq, O., and Grossman, M.I., 1975, Inhibition of gastric emptying is a physiological action of cholecystokinin, Gastroenterology, 68:1211.

    PubMed  CAS  Google Scholar 

  • De Ponti, F., Azpiroz, F., Malagelada, H.R., 1987, Reflex gastric relaxation in response to distension of the duodenum, Am. J. Physiol., 252:G595.

    Google Scholar 

  • Dinn, T.T., and Ritter, S., 1985, Capsaicin induces neuronal degeneration in the brain and spinal cord of adult rats, Soc. Neurosci., 11:349.

    Google Scholar 

  • Evangelista, S., Santicioli, P., Maggi, C.A., and Meli, A., 1989, Increase in gastric secretion induced by 2-deoxy-D-glucose is impaired in capsaicin pretreated rats, Brit. J. Pharmacol., 98:35.

    Article  CAS  Google Scholar 

  • Feldmen, M., Dickerson, R.M., McClelland, R.N., Cooper, K.A., Walsh, J.H., and Richardson, C.T., 1979, Effect of selective proximal vagotomy on food-stimulated gastric acid secretion and gastrin release in patients with duodenal ulcer, Gastroenterology, 76:926.

    Google Scholar 

  • Fried, M., Lochner, C., Erlacher, U., Beglinger, C., Jansen, J., Lamers, J., and Stadler, G.A., 1989, Role of CCK in the regulation of gastric emptying and pancreatic secretion in man, Gastroenterology, 96: A159.

    Google Scholar 

  • Gamse, R., Petsche, U., Lembeck, F., and Jansco, G., 1982, Capsaicin applied to peripheral nerve inhibits axoplasmic transport of substance P and somatostatin, Brain Res., 239:447.

    Article  PubMed  CAS  Google Scholar 

  • Green, T., and Dockray, G.J., 1988, Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea pig, Neurosci., 25:181.

    Article  CAS  Google Scholar 

  • Green, T., Dimaline, R., and Dockray, G.J., 1989, Neuroendocrine control mechanisms of gastric emptying in the rat, in: “Nerves and the Gastrointestinal Tract,” M.V. Singer and H. Goebell, eds., Kluwar, Netherlands.

    Google Scholar 

  • Green, T., Dimaline, R., Peikin, S., and Dockray, G.J., 1988, The action of the cholecystokinin antagonist L364,718 on gastric emptying of liquid meals in the conscious rat, Am. J. Physiol., 255:G685.

    Google Scholar 

  • Grundy, D., and Scratcherd, T., 1989, Sensory afferents from the gastrointestinal tract, in: “Handbook of Physiology,” Volume 6, Chapter 10.

    Google Scholar 

  • Guth, P.H., and Leung, F.W., 1987, Physiology of the gastric circulation, in: “Physiology of the Gastrointestinal Tract,” L.R. Johnson,ed., Raven Press, New York.

    Google Scholar 

  • Guth, P.H., and Smith, E., 1977, Nervous regulation of the gastric microcirculation, in: “Nerves and the Gut,” F.P. Brooks and P.W. Ewers, eds., C.B. Stack, New York.

    Google Scholar 

  • Higashi, H., 1986, Pharmacological aspects of visceral sensory receptors, Progress in Brain Research, 67:149.

    Article  PubMed  CAS  Google Scholar 

  • Holzer, P., 1988, Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides, Neurosci., 24:739.

    Article  CAS  Google Scholar 

  • Holzer, P., Taché, Y. and Guth, P.H., 1990, The vasodilator neuropeptides α-CGRP and VIP, but not substance P and neurokinin Ä, increase rat gastric mucosal blood flow, Gastroenterology, 98:A175.

    Article  Google Scholar 

  • Holzer, P., Peskar, B.M., Peskar, B.A., and Amman, R., 1990, Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach, Neurosci. Lett., 109:195.

    Article  Google Scholar 

  • Jansco, G., Kiraly, E., and Jansco-Gabor, A., 1980, Direct evidence for an axonal site of action of capsaicin, N.S. Arch. Pharmacol., 313:91.

    Google Scholar 

  • Jansco, G., and Such, G., 1983, Effects of capsaicin applied pe-rineurally to the vagus nerve on cardiovascular and respiratory functions in the cat, J. Physiol. Lond., 341:359.

    Google Scholar 

  • Ladenheim, E.E., Speth, R.C., and Ritter, R.C., 1988, Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats, Brain Res., 474:125.

    Article  PubMed  CAS  Google Scholar 

  • Leung, R.V., Guth, P.H., Scremin, O.U., Golanska, E.M., and Kauffman, G.L., Jr., 1984, Regional gastric mucosal blood flow measurements by hydrogen gas clearance in the anesthetized rat and rabbit, Gastroenterology, 87:28.

    PubMed  CAS  Google Scholar 

  • Liddle, R.A., Green, G.M., Conrad, C.K., and Williams, J.A., 1986, Proteins but not amino acids, carbohydrates or fats stimulate cholecystokinin secretion in the rat, Am. J. Physiol., 251:G243.

    Google Scholar 

  • Liddle, R.A., Morita, E.T., Conrad, C.K., and Williams, J.A., 1986, Regulation of gastric emptying in humans by cholecystokinin, J. Clin. Invest., 77:992.

    Article  PubMed  CAS  Google Scholar 

  • Lotti, V.J., Pendleton, R.G., Gould, R.J., Hanson, H.M., Chang, R.S., and Clineschmidt, B.V., 1987, In vivo pharmacology of L-364,718, a new potent nonpeptide cholecystokinin antagonist, J. Pharmacol. Exp. Ther., 241:103.

    PubMed  CAS  Google Scholar 

  • Lundberg, J.M., and Saria, A., 1987, Polypeptide-containing neurons in airway smooth muscle, Ann. Rev. Physiol., 49:557.

    Article  CAS  Google Scholar 

  • Lynn, B., 1987, The immediate and long-term effects of applying capsaicin to cutaneous nerves, Acta Physiol. Hung., 69:287.

    PubMed  CAS  Google Scholar 

  • Martinson, J., 1964, The effect of graded stimulating of efferent vagal nerve fibers on gastric motility, Acta Physiol. Scand., 62:256.

    Article  PubMed  CAS  Google Scholar 

  • McCann, M.J., Hermann, G.E., and Rogers, R.C., 1989, Thyrotro-pin-releasing hormone: effects on identified neurons of the dorsal vagal complex, J. Auton. Nerv. System., 26:107.

    Article  CAS  Google Scholar 

  • Mei, N., 1985, Intestinal chemosensitivity, Physiol. Rev., 65:211.

    PubMed  CAS  Google Scholar 

  • Moran, T.H., Smith, G.P., Hostetler, A.M., and McHugh, P.R., 1987, Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches, Brain Res., 415:149.

    Article  PubMed  CAS  Google Scholar 

  • Morishito, T., and Guth, P.H., 1986, Vagal nerve stimulation causes noncholinergic dilatation of gastric arterioles, Am. J. Physiol., 250:G660.

    Google Scholar 

  • Murphy, R.B., Smith, G.P., and Gibbs, J., 1987, Pharmacological examination of cholecystokinin (CCK-8)-induced contractile activity in the rat isolated pylorus, Peptides, 8:127.

    Article  PubMed  CAS  Google Scholar 

  • Okike, N., and Kelly, K.A., 1977, Vagotomy impairs pentagastrin-induced relaxation of canine gastric fundus, Am. J. Physiol., 232:E504.

    Google Scholar 

  • Pederson, R., O’Dorisio, T., Howe, T., Macintosh, B., Mueller, M., Brown, J., and Cataland, S., 1981, Vagal release of IR-VIP and IR-gastrin from the isolated perfused rat stomach, Mol. Cell. Endocrinol., 23:225.

    Article  PubMed  CAS  Google Scholar 

  • Pendleton, R.G., Bendesky, R.J., Schaffer, L., Nolan, T.E., Gould, R.J., and Clineschmidt, B.V., 1987, Roles of endogenous cholecystokinin in biliary, pancreatic and gastric function: studies with L-364,718, a specific cholecystokinin receptor antagonist, J. Pharmacol. Exp. Ther., 241:110.

    PubMed  CAS  Google Scholar 

  • Peter, E.T., Nicoloff, D.M., Leonard, A.S., Walder, A.L., and Wangensteen, O.H., 1963, Effect of vagal and sympathetic stimulation and ablation on gastric blood flow, JAMA, 183:1003.

    Article  PubMed  CAS  Google Scholar 

  • Raybould, H.E. and Davison, J.S., 1989, Perivagal application of capsaicin abolishes the response of vagal gastric mechano-receptor to cholecystokinin, Soc. Neurosci., 15:973.

    Google Scholar 

  • Raybould, H.E., Holzer, P., Reddy, S.N., Yang, H. and Tache, Y., 1990, Capsaicin-sensitive vagal afferents contribute to gastric acid and vascular responses to intracisternal TRH analog, Peptides, in press.

    Google Scholar 

  • Raybould, H.E., Koelbel, C.B., Mayer, E.A. and Taché, Y., 1990, Inhibition of gastric motor function by circulating corti-cotropin-releasing factor in anaesthetized rats, J. Gastrointest. Motility, in press.

    Google Scholar 

  • Raybould, H.E., Roberts, M.E. and Dockray, G.J., 1987, Reflex decreases in intragastric pressure in response to cholecystokinin in rats, Am. J. Physiol., 253:G165.

    Google Scholar 

  • Raybould, H.E., and Tache, Y., 1988, Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats, Am. J. Physiol., 255:G242.

    Google Scholar 

  • Raybould, H.E., and Tache, Y., 1989, Gastric distension and histamine stimulate gastric acid secretion by capsaicin-sensitive vagal afferent pathway in the anesthetized rat, Eur. J. Pharmacol., 167:237.

    Article  PubMed  CAS  Google Scholar 

  • Rogers, R.C, and McCann, M.J., 1989, Effects of TRH on the activity of gastric inflation-related neurons in the solitary nucleus in the rat, Neurosci. Lett., 104:71.

    Article  PubMed  CAS  Google Scholar 

  • Rozsa, Z., Varro, A., and Jansco, G., 1985, Use of immunoblockade to study the involvement of peptidergic afferent nerves in the intestinal vasodilatory response to capsaicin in the dog, Europ. J. Pharmacol., 115:59.

    Article  CAS  Google Scholar 

  • Schiller, L.R., Walsh, J.H., and Feldman, M., 1980, Distension-induced gastrin release: effects of luminal acidification and intravenous atropine, Gastroenterology, 78:912.

    PubMed  CAS  Google Scholar 

  • Smith, G.P., Falasco, J., Moran, T.H., Joyner, K.M.S., and Gibbs, J., 1988, CCK-8 decreases food intake and gastric emptying after pylorectomy or pyloroplasty, Am. J. Physiol., 255:R113.

    Google Scholar 

  • Sternini, C., Reeve, J.R., and Brecha, N., 1987, Distribution and characterization of calcitonin gene-related peptide immunoreactivity in the digestive system of normal and capsaicin-treated rats, Gastroenterology, 93:852.

    PubMed  CAS  Google Scholar 

  • Swan, K.G., and Jacobson, E.D., 1967, Gastric mucosal blood flow and secretion in conscious dogs, Am. J. Physiol., 212:891.

    PubMed  CAS  Google Scholar 

  • Tache, Y., Stephens, R.L., and Ishikawa, T., 1989, Central nervous system action of TRH to influence gastrointestinal function and ulceration, Ann. N.Y. Acad. Sci., 553:169.

    Article  Google Scholar 

  • Thiefin, G., Tache, Y., Leung, F.W., and Guth, P.H., 1989, CNS actions of thyrotropin-releasing hormone to increase gastric mucosal blood flow in the rat, Gastroenterology, 97:405.

    PubMed  CAS  Google Scholar 

  • Thiefin, G., Raybould, H., Leung, F.W., Tache, Y., and Guth, P.H., 1990, Capsaicin-sensitive vagal afferent fibers contribute to gastric mucosal blood flow response to electrical stimulation, Am. J. Physiol., in press.

    Google Scholar 

  • Vagne, M., Konturek, S.J., and Chayvialle, J.A., 1982, Effect of vasoactive intestinal peptide on gastric secretion in the cat, Gastroenterology, 83:250.

    PubMed  CAS  Google Scholar 

  • Wall, P.D., and Fitzgerald, M., 1981, Effects of capsaicin applied locally to adult peripheral nerve. I. Physiology of peripheral nerve and spinal cord, Pain, 11:363.

    Article  PubMed  CAS  Google Scholar 

  • Yamagishi, T., and Debas, H.T., 1978, Cholecystokinin inhibits gastric emptying by acting on both proximal stomach and pylorus, Am. J. Physiol., 234:E375.

    Google Scholar 

  • Yanigasawa, K., Yang, H., Walsh, J.H., and Tache, Y., 1990, Role of acetylcholine, histamine and gastrin in the acid response to intracisternal injection of TRH analog, RX77368, in the rat, Regul. Peptides, 27:161.

    Article  Google Scholar 

  • Yanigasawa, Y. and Tache, Y., 1990, Central vagal stimulation by intracisternal injection of TRH analog, RX77368 increases gastric histamine secretion in the rat, Gastroenterology, 98:A151.

    Google Scholar 

  • Yano, S.A., Fujiwara, A., Ozaki, Y., and Harada, M., 1983, Gastric blood flow responses to autonomic nerve stimulation and related pharmacological studies in rats, J. Pharm. Pharmacol., 35:641.

    Article  PubMed  CAS  Google Scholar 

  • Zarbin, M.A., Wamsley, J.K., Innis, R.B., and Kuhar, M.J., 1981, Cholecystokinin receptors: presence and axonal flow in the rat vagus nerve, Life Sciences, 29:696.

    Article  Google Scholar 

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Authors and Affiliations

  1. Center for Ulcer Research and Education, VA West Los Angeles, USA

    Helen E. Raybould, Peter Holzer, Gerard Thiefin, Helge H. Holzer, Masashi Yoneda & Yvette F. Tache

  2. Department of Medicine and Brain Research Institute, University of California, Los Angeles, USA

    Helen E. Raybould, Peter Holzer, Gerard Thiefin, Helge H. Holzer, Masashi Yoneda & Yvette F. Tache

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  1. Helen E. Raybould
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  2. Peter Holzer
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  3. Gerard Thiefin
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  4. Helge H. Holzer
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  5. Masashi Yoneda
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  6. Yvette F. Tache
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Editors and Affiliations

  1. Flinders University of South Australia, Adelaide, Australia

    Marcello Costa

  2. University of Florence, Florence, Italy

    Calogero Surrenti

  3. Fondazione Internazionale Menarini, Florence, Italy

    Sergio Gorini

  4. A. Menarini Pharmaceuticals, Florence, Italy

    Carlo Alberto Maggi  & Alberto Meli  & 

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Raybould, H.E., Holzer, P., Thiefin, G., Holzer, H.H., Yoneda, M., Tache, Y.F. (1991). Vagal Afferent Innervation and Regulation of Gastric Function. In: Costa, M., Surrenti, C., Gorini, S., Maggi, C.A., Meli, A. (eds) Sensory Nerves and Neuropeptides in Gastroenterology. Advances in Experimental Medicine and Biology, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0744-8_10

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  • DOI: https://doi.org/10.1007/978-1-4899-0744-8_10

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