Abstract
There is ample evidence that the primary target of platinum anti-tumor drugs is DNA, which has caused much interest in the chemistry of platinum complexes of nucleobases.1 If, however, one wishes fully to understand the biological chemistry of the platinum compounds, it is also necessary to consider their interaction with other potential ligands which are present in vivo. Among the more important of these are proteins, peptides, and amino acids. Reaction of platinum drugs with these compounds may have the following effects:2
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(i)
To the extent that the platinum compounds react with such molecules, they are prevented from reacting with the target DNA.
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(ii)
Some of the toxic side-effects of platinum drugs are due to platinum-protein interactions.
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(iii)
Some forms of resistance of tumor cells toward platinum drugs may be due to enhanced coordination by peptides and proteins.
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Appleton, T.G., Hall, J.R., Prenzler, P.D., Ross, F.B. (1991). Complexes of Peptides and Related Molecules with Diammineplatinum (II) as Models for Platinum-Protein Interactions. In: Howell, S.B. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0738-7_6
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DOI: https://doi.org/10.1007/978-1-4899-0738-7_6
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