Improved Efficacy of “Two-route Chemotherapy” Using Cisplatin and its Antidote, Sodium Thiosulfate, in Combination with Angiotensin II
For unresectable but regionally confined malignant tumors, local chemotherapy using intra-arterial or intraperitoneal injection of an anti-cancer drug has been widely and effectively used in the clinical field. However, the dose of locally administered anti-cancer drugs is limited because of the general toxicity which is induced by the drug entering the systemic circulation from the tumor site. In an attempt to overcome this problem, we previously designed a combination chemotherapy, termed two-route chemotherapy (TRC), using a local injection of high-dose anti-cancer drug and the systemic administration of its antidote1. This treatment was devised to increase the anti-tumor effect by giving high doses of an anti-cancer drug at the tumor site while reducing the general toxicity of the drug with an antidote. Since cis-diamminedichloroplatinum(II) (DDP) is potent against a wide range of human tumors and sodium thiosulfate (STS) effectively and safely detoxicates DDP in vivo2,3, we mainly used DDP as the anti-cancer agent and STS as its antidote. We have previously reported on the remarkable effectiveness of TRC against liver tumors4, urinary bladder tumors5, peritoneally disseminated tumors6, lung tumors7, and limb tumors8 in experimental animals. TRC has also been effectively used for treating human cancer in Japan9, 10.
KeywordsRenal Blood Flow Tumor Blood Flow Systolic Arterial Blood Pressure Selective Enhancement Left Femoral Vein
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