High-Dose Carboplatin with Peripheral Blood Stem Cell and Growth Factor Support
The administration of high-dose chemotherapy has resulted in a marked increase in the frequency of both partial and complete responses in a large number of patients with solid and hematologic malignancies. This approach has led to long term remission and probable cure rates of 20–60% in patients with Hodgkin’s and non-Hodgkin’s lymphoma. Similar results have also been obtained in treating children with neuroblastoma and adults with first and second remission acute myelogenous leukemia1,2. While data on the long term results of high-dose therapy in breast cancer patients is less extensive, several reports do suggest that such regimens can prolong disease free survival for patients treated early in the course of their metastatic disease or in the adjuvant setting for women at high risk of early relapse3–6.
KeywordsClin Oncol Peripheral Blood Stem Cell Capillary Leak Syndrome Germ Cell Cancer Growth Factor Support
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- 2.F.R. Appelbaum, Marrow transplantation for hematologic malignancies: a brief review of current status and future prospects, Sem in Hem 25(Suppl 3):16–22 (1988).Google Scholar
- 4.F.R. Dunphy, G. Spitzer, A.U. Buzdar, G.N. Hortobagyi, L.J. Horwitz, J.C. Yau, J.A. Spinolo, S. Jagannath, F. Holmes, R.O. Wallerstein, P.A. Bohannan, and K.A. Dicke, Treatment of estrogen receptor-negative or hormonally refractory breast cancer with double high-dose chemotherapy intensification and bone marrow support, J Clin Oncol 8:1207–1216 (1990).PubMedGoogle Scholar
- 8.C.A. Juttner, L.B. To, D.N. Haylock, A. Branford, and R.J. Kimber, Circulating autologous stem cells collected in very early remission from acute non-lymphoblastic leukaemia produce prompt but incomplete haemopoietic reconstitution after high dose melphalan or supralethal chemoradiotherapy, Br J Haem 61:739–745 (1985).CrossRefGoogle Scholar
- 11.A.M. Gianni, S. Siena, M. Bregni, C. Tarella, A.C. Stern, A. Pileri, and G. Bonadonna, Granulocyte-macrophage colony-stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation, The Lancet 580-585 (September 9, 1989).Google Scholar
- 12.W.P. Peters, J. Kurtzberg, G. Kirkpatrick, S. Atwater, C. Gilbert, M. Borowitz, E. Shpall, R. Jones, M. Ross, M. Affronti, D. Coniglio, B. Mathias, and D. Oette, GM-CSF primed peripheral blood progenitor cells (PBPC) coupled with autologous bone marrow transplantation (ABMT) will eliminate absolute leukopenia following high dose chemotherapy (HDC), Proc ASCO 9:178 (1990).Google Scholar