Abstract
The hypothesis that larger dose-time quotients of chemotherapy result in improved therapeutic outcome is firmly fixed in modern oncologic thought and practice. This hypothesis has enjoyed currency not only for the intuitive “rightness” of the concept, but based on the results of carefully conducted retrospective analysis of clinical trials which often demonstrate superior outcome in patients receiving more dose-intensive treatments. Unfortunately, there are only a handful of randomized prospective trials adequately testing this hypothesis.
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References
Daugaard, G. and M. Rorth, 1986, High-Dose Cisplatin and VP-16 with Bleomycin, in the Management of Advanced Metastatic Germ Cell Tumors, Eur J Cancer Clin Oncol, 22: 477.
Droz, J. P., J. L Pico, M. Ghosn, M. Ostronoff, A. Azab, A. Rey, B. H. Court and M. Hayat, 1989, High Complete Remission (CR) and Survival Rates in Poor Prognosis (PP) Nonseminomatous Germ Cell Tumors (NSGCT) with High Dose Chemotherapy and Autologous Bone Marrow Transplantation (ABMT), Proc Am Soc Clin Oncol, 8: 130.
Einhorn, L H. and S. D. Williams, 1980, Chemotherapy of Disseminated Testicular Cancer: A Random Prospective Study, Cancer. 46: 1339.
Figuerado, A. T., W. M. Hryniuk, I. Strautmanis, G. Frank and S. Rendell, 1985, Cotrimazole Prophylaxis During High Dose Chemotherapy of Small Cell Lung Cancer, J Clin Oncol, 3: 54.
Frei III, E., B. A. Teicher, S. A. Holden, K. N. S. Cathcart and Y. Wang, 1988, Preclinical Studies and Clinical Correlation of the Effect of Alkylating Dose, Cancer Res. 48: 6417.
Hande, K. R., R. K. Oldham, M. F. Fer, R. L Richardson and F. A. Greco,1982, Randomized Study of High-Dose Versus Low Dose Metotrexate in Treatment of Extensive Small Cell Lung Cancer, Am J Med, 73: 413.
Henderson, I. C., D. F. Hayes and R. Gelman, 1988, Dose-Response in the Treatment of Breast Cancer: A Critical Review, J Clin Oncol, 6(9): 1501.
Hortobagyi, G. N., G. P. Bodey, A. U. Buzar, D. Frye, S. Legha, R. Malik, T. L Smith, G. R. Blumenschein, H. Yap and V. Rodrriguez, 1987, Evaluation of High-Dose Versus Standard FAC Chemotherapy for Advanced Breast Cancer to Protected Environment Units: A Prospective Randomized Study, J Clin Oncol, 5: 354.
Hryniuk, W. M. and H. Bush, 1984, The Importance of Dose-Intensity in Chemotherapy for Metastatic Breast Cancer, J Clin Oncol, 2: 1281.
Nichols, C. R., G. Tricot, S. D. Williams, K. van Besian, P. J. Loehrer, B. J. Roth, L Akard, R. Hoffman, R. Goulet, S. N. Wolff, L. Giannone, J. Greer, L. H. Einhorn and J. Jansen, 1989, Dose-Intensive Chemotherapy in Refractory Germ Cell Cancer-A Phase I/II Trial of High Dose Carboplatin and Etoposide with Autologous Bone Marrow Transplantation, J Clin Oncol, 7: 932.
O’Bryan, R. M., L. H. Baker, J. E. Gottlieb, S. E. Rivkin, S. P. Balcherzak, G. N. Grumet, S. E. Salmon, T. E. Moon and B. Hoogstraten, 1977, Dose Response Evaluation of Adriamycin in Human Neoplasia, Cancer, 39: 1940.
Ozols, R. F., B. J. Corden, J. Jacobs, M. N. Wesley, Y. Ostchega and R. C. Young, 1984, High-Dose Cisplatin in Hypertonic Saline, Ann intern Med, 100: 19.
Ozols, R. F., D. C. Ihde, M. Linehan, J. Jacob, Y. Ostchega and R. C. Young 1988, A Randomized Trial of Standard Chemotherapy vs High-Dose Chemotherapy Regimen in the Treatment of Poor Prognosis Nonseminomatous Germ-Cell Tumors, J Clin Oncol, 6(6): 1031.
Pizzocaro, G., L. Piva, R. Salvoioni, F. Zanoni and A. Milani, 1985, Cisplatin, Etoposide, Bleomycin First-Line Therapy and Early Resection of Residual Tumor in Far-Advanced Germinal Testis Cancer, Cancer, 56: 2411.
Sampson, M. K., S. E. Rivkin, S. E. Jones, J. J. Costanzi, A. F. LoBuglio, R. L. Stephens, E. A. Gehan and G. D. Cummings, 1984, Dose-Response and Dose-Survival Advantage for High Versus Low-Dose Cisplatin Combined with Vinblastine and Bleomycin in Disseminated Testicular Cancer A Southwest Oncology Group Study, Cancer, 53: 1029.
Schmoll, H. J., I. Schubert, H. Arnold, G. Dolken, T. Hecht, L. Bergmsnn, J. Illiger, U. Fink, J. Preiss, M. Dfreundschuh, H. Kaulen, B. Bonfert, A. D. Ho, C. Manegold, A. Mayr, L. Hoffmann, J. Weiss and H. Hecker, 1987, Disseminated Testicular Cancer with Bulky Disease: Results of a Phase II Study with Cisplatin Ultra High Dose/VP-16/Bleomycin, Int J Androl, 10: 311.
Stoter, G., D. T. Sleyfer and W. W. ten Bokkel Huinink, 1986, High Dose Versus Low Dose Vinblastine in Cisplatin-Vinbalstine Bleomycin Combination Chemotherapy of Nonseminomatous Testicular Cancer: A Randomized Study of the EORTC Genitourinary Tract Cancer Cooperative Group, J Clin Oncol, 4(8): 1199.
Williams, S. D., R. Birch, L H. Einhorn, L Irwin, F. A. Greco and P. J. Loehrer, 1987, Treatment of Disseminated Germ-Cell Tumors with Cisplatin, Bleomycin and either Vinblastine or Etoposide, N Engl J Med, 316: 1435.
Wolff, S. N., R. Birch, P. Sarma and F. A. Greco, 1986, Randomized Dose-Response Evaluation of Etoposide in Small Cell Carcinoma of the Lung: A Southeastern Cancer Study Group Trial, Cancer Treat Rep 70: 583.
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© 1991 Springer Science+Business Media New York
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Nichols, C.R., Williams, S.D., Loehrer, P.J., Einhorn, L.H. (1991). Cisplatin Dose-intensity in Testicular Cancer Treatment: Analysis of a Randomized Clinical Trial. In: Howell, S.B. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0738-7_38
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