Modelling Platinum-DNA Interactions

  • Bernhard Lippert
  • Gudrun Frommer
  • Oliver Renn
  • Olga Krizanovic
  • Iris Dieter
  • Michael Krumm
  • Gabriele Trotscher
  • Ferdinand Pesch
  • Frank Schwarz
  • Stephan Menzer
  • Edda C. Hillgeris

Abstract

The understanding of the effects of a small molecule such as cis-diamminedichloroplatinum(II) (Cisplatin, cis-DDP) on a biomacromolecule, e.g. DNA, or on the biology of a whole cell starts with the molecular level. Model studies at various degrees of complexity — with isolated model nucleobases, nucleosides, nucleotides and oligonucleotides1–8* — have greatly contributed to our present understanding of metal-DNA interactions in general and those of cis-DDP and DNA in particular. Despite obvious limitations and shortcomings, work with isolated model nucleobases is meaningful in that fundamental questions such as binding patterns and ligand rotation processes may be conveniently studied. In the following, mainly results from own studies on the interactions of mono-and difunctional Pt electrophiles with N1 methylated pyrimidine nucleobases (1-methylcytosine, 1-MeC or C, 1-methylthymine, 1-MeTH or TH, 1-methyluracil, 1-MeUH or UH) and N9 alkylated purine nucleobases (9-methyladenine, 9-MeA or A, 9-methylguanine, 9-MeGH or GH, 9-ethylguanine, 9-EtGH or GH) will be discussed**.

Keywords

Platinum Complex Nitrate Trihydrate Linkage Isomerization Platinum Blues Guanine Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Bernhard Lippert
    • 1
  • Gudrun Frommer
    • 1
  • Oliver Renn
    • 1
  • Olga Krizanovic
    • 1
  • Iris Dieter
    • 1
  • Michael Krumm
    • 1
  • Gabriele Trotscher
    • 1
  • Ferdinand Pesch
    • 1
  • Frank Schwarz
    • 1
  • Stephan Menzer
    • 1
  • Edda C. Hillgeris
    • 1
  1. 1.Fachbereich ChemieUniversität DortmundDortmundGermany

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