Sensitization of Resistant Human Tumor Cells to Cisplatin or Carboplatin by Inhibitors of DNA Excision Repair

  • Lode J. Swinnen
  • Nancy Ellis
  • Leonard C. Erickson

Abstract

Cis-diamminedichloroplatinum(II) (cis-DDP) is one of the most effective drugs currently available for the treatment of human neoplasms. There is compelling evidence that DNA is the drug’s principal biological target.1,2 While the nature and relative frequency of cis-DDP induced DNA adducts have been elucidated3,4 the relative contribution to cytotoxicity and the mechanisms responsible for the repair of each of these lesions remain poorly defined. Understanding the repair systems involved in the removal of cis-DDP induced DNA adducts may well be of fundamental importance in developing strategies for modulating tumor resistance to this drug.

Keywords

Xeroderma Pigmentosum Interstrand Crosslinking Alkaline Elution Intrastrand Crosslinks Xeroderma Pigmentosum Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Lode J. Swinnen
    • 1
  • Nancy Ellis
    • 1
  • Leonard C. Erickson
    • 1
  1. 1.Section of Hematology/Oncology, Department of Medicine, Stritch School of MedicineLoyola University ChicagoMaywoodUSA

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