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A Protein from Mammalian Cells that Recognizes Platinated DNA

  • Brian A. Donahue
  • Steven F. Bellon
  • Stephen J. Lippard
  • John M. Essigmann

Abstract

The anticancer drug cis-diamminedichloroplatinum(II) (cis-DDP or cisplatin), is believed to kill cells by blocking DNA replication or transcription (Roberts and Thomson, 1979; Sorenson and Eastman, 1988a, b). cis-DDP-DNA adducts have been shown to block DNA replication in vitro (Pinto and Lippard, 1985b; Heiger-Bernays et al., 1990) and in vivo (Harder and Rosenberg, 1970; Howie and Gale, 1970; Ciccarelli et al., 1985). Similar recent studies have shown that selected platinum adducts also inhibit RNA polymerases (Corda et al., 1991).

Keywords

HeLa Cell Platinum Compound Ammonium Sulfate Fraction Placental Extract Slow Migrate Band 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Brian A. Donahue
    • 1
    • 2
  • Steven F. Bellon
    • 1
  • Stephen J. Lippard
    • 1
  • John M. Essigmann
    • 1
    • 2
  1. 1.Department of ChemistryMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Whitaker College of Health Sciences and TechnologyMassachusetts Institute of TechnologyCambridgeUSA

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