Repair of Damaged DNA In Vitro by Extracts from Human Cell Lines

  • Richard D. Wood


In order to maintain the continuity of the genome, organisms devote many enzymes and regulatory proteins to the repair of spontaneous and environmentally induced DNA damage (Friedberg, 1985). One of the principal repair pathways is DNA excision repair, which acts to remove a segment of a damaged DNA strand and replace it with nondamaged nucleotides. The process acts on a remarkable diversity of DNA lesions, including those produced by ultraviolet light (UV) irradiation and by a variety chemical mutagens (Pu et al., 1989; Van Houten, 1990).


Excision Repair Xeroderma Pigmentosum Cyclobutane Pyrimidine Dimer Repair Synthesis Xeroderma Pigmentosum Patient 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Richard D. Wood
    • 1
  1. 1.Imperial Cancer Research FundClare Hall LaboratoriesSouth Mimms, HertsUK

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