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Molecular Aspects of Repair and Mutagenesis of cis-Platinum-Induced Lesions

  • Dominique Burnouf
  • Corinne Gauthier
  • Jean-Claude Chottard
  • Robert P. P. Fuchs

Abstract

The conversion of DNA lesions into mutations is an active biochemical process. Due to the remarkable efficiency of the error free repair mechanisms only a very small number of DNA lesions will eventually be processed into a mutation. Indeed, under normal conditions, less than one percent of DNA lesions give rise to mutations. This makes the biochemical study of the mechanisms involved in mutagenesis very difficult. As a first molecular approach, the study of the mutational specificity of a given mutagen will provide important informations concerning the mechanisms that are involved. This is particularly true if the analysis of the mutational specificity can be performed in hosts having altered genotypes for repair and (or) mutagenesis. Bacteria are in this respect the organisms of choice, due to the large number of existing repair, replication and recombination mutants.

Keywords

Mutation Frequency Excision Repair Plasmid pBR322 Base Pair Substitution Tetracycline Resistance Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Dominique Burnouf
    • 1
  • Corinne Gauthier
    • 2
  • Jean-Claude Chottard
    • 2
  • Robert P. P. Fuchs
    • 1
  1. 1.Groupe de Cancérogenèse et de Mutagenèse Moléculaire et StructuraleIBMC du CNRSStrasbourgFrance
  2. 2.Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, UA400 CNRSParisFrance

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