Abstract
The conversion of DNA lesions into mutations is an active biochemical process. Due to the remarkable efficiency of the error free repair mechanisms only a very small number of DNA lesions will eventually be processed into a mutation. Indeed, under normal conditions, less than one percent of DNA lesions give rise to mutations. This makes the biochemical study of the mechanisms involved in mutagenesis very difficult. As a first molecular approach, the study of the mutational specificity of a given mutagen will provide important informations concerning the mechanisms that are involved. This is particularly true if the analysis of the mutational specificity can be performed in hosts having altered genotypes for repair and (or) mutagenesis. Bacteria are in this respect the organisms of choice, due to the large number of existing repair, replication and recombination mutants.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Fuchs, R.P.P., Schwartz, N. and Daune, M.P. (1981) Nature (London) 294, 657–659.
Koffel-Schwartz, N., Verdier, J.M., Bichara, M., Freund, A.M., Daune, M.P. and Fuchs, R.P.P. (1984) J. Mol. Biol. 177, 33–51.
Bichara, M. and Fuchs, R.P.P. (1985) J. Mol. Biol. 183, 341–351.
Basu, A.K. and Essigman, J.M. (1988) Chem. Res. Toxicol. 1, 1–18.
Banerjee, S.K., Christensen R.B., Lawrence C.W., and Leclerc, J.E.(1988) Proc. Natl.Acad. Sci. USA, 85, 8141–8145.
Loechler, E.L., Green, C.L. and Essigman, J.M. (1984) Proc. Natl.Acad. Sci. USA 81, 6271–6275.
Lasko, D.D., Harvey, S.C., Malaikal, S.B., Kadlubar, F.F. and Essigman, J.M. (1988) J. Biol. Chem. 263, 15429–15435.
Burnouf, D., Koehl, P. and Fuchs, R.P.P. (1989) Proc. Natl. Acad. Sci. USA 86, 4147–4151.
Van Houten, B., Gamper, H., Hearst, J.E., and Sancar, A. (1988) J. Biol. Chem., 263, 16553–16560.
Koehl, P., Valladier, P., Lefevre, J.F. and Fuchs, R.P.P. (1989) Nucleic Acids Res., 17, 9531–9541.
Kemmink, J., Boelens, R., Koning, T., van der Marel, G.A., Van Boom, J.H., Kaptein, R. (1987) Nucl. Acids Res. 15, 4645–4653.
Van Hemelryck, B., Guittet, E., Chottard, G., Girault, J.P., Huynh-Dinh, T., Lallemand, J.Y., Igolen, J. and Chottard, J.C (1984) J. Amer. Chem. Soc. 106, 3037–3039.
Husain, I., Griffith, J. and Sancar, A. (1988) Proc. Natl. Acad. Sci. USA 85, 2558–2562.
Rice J.A., Crothers, D.M., Pinto A.L. and Lippard, S.J. (1988) Proc. Natl. Acad. Sci. USA 85, 4158–4161.
Den Hartog, J.H.J., Altona, C., Van Boom, J.H., Van der Marel, G.A., Haasnoot, C.A.G. and Reedijk, J. (1985) J. Biomol. Struct. Dyn. 2, 1137–1155.
Seeberg, E. and Fuchs, R.P.P., (1990) Proc. Natl. Acad. Sci. USA, 87, 191–194.
Page J.D., Husain I., Chaney S.G. and Sancar A. (1987), in “Platinum and other metal coordination compounds in Cancer Chemotherapy”, Martinus Nighoff-Publishing, 115-126.
Page, J. D., Husain, I., Sancar, A., and Chaney, S.G. (1990) Biochemistry, 29, 1016–1024.
Girault, J.P., Chottard, J.C, Guittet, E.R., Lallemand, J.Y., Huynh-Dinh T. and Igolen, J.(1982) Biochem. Biophys. Res. Commun. 109, 1157–1163.
Caradonna, J.P., Lippard, S.J., Gait, M.J. and Singh, M. (1982) J. Amer. Chem. Soc. 104, 5793–5795.
Sherman S. and Lippard S.J. (1988) Chem. Rev., 87, 1153–1181.
Eastman, A. (1983) Biochemistry 22, 3927–3933.
Fichtinger-Schepman, A.M.J., Van der Meer, J.L., den Hartog, J.H.J., Lohman, P.H.M. and Reedijk, J. (1985) Biochemistry 24, 707–713.
Eastman, A. (1986) Biochemistry 25, 3912–3915.
Husain, I., Chaney, S.G., and Sancar, A. (1985) J. Bacteriol., 163, 817–823.
Beck, D.J., Popoff, S., Sancar, A., and Rupp, W.D. (1985) Nucl. Acids Res., 13, 7395–7412.
Popoff, S.C., Beck, D.J., Rupp, W.D., (1987) Mutat. Res., 183, 129–137.
Koffel-Schwartz, N., Maenhaut-Michel, G. and Fuchs, R.P.P. (1987) J. Mol. Biol. 193, 651–659.
Burnouf, D., Daune, M. and Fuchs, R.P.P. (1987) Proc. Natl. Acad. Sci. USA 84, 3758–3762.
Burnouf, D., Gauthier, C., Chottard, J.-C., and Fuchs, R.P.P., (1990) Proc. Nat. Acad. Sci. USA 87, 6087–6091.
Koehl, P., Burnouf, D., and Fuchs, R.P.P. (1989) J. Mol. Biol. 207, 355–364.
Piette, J., Gamper, H.B., van de Vorst, A., and Hearst, J.E. (1988) Nucleic Acids Res. 16, 9961–9977.
Kozelka, J., Petsko, G.A., Lippard, S.J. (1985) J. Amer. Chem. Soc. 107, 4079–4081.
Kozelka, J., Petsko, G.A., Quigley, G.J., Lippard, S.J. (1986) Inorg. Chem. 25, 1075–1077.
Marrot, L. and Leng, M. (1989) Biochemistry 28, 1454–1461.
Den Hartog, J.H.J., Altona, C, Chottard, J.C., Girault, J.P., Lallemand, J.Y., de Leeuw, F.A.A.M., Marcellis, A.T.M. and Reedijk, J. (1982) Nucl. Acids Res. 10, 4715–4730.
Herman F., Kozelka J., Guittet E., Storen V., Huynh-Dinh T., Igolen J., Lallemand J.Y. and Chottard J.C., submitted.
Van Hemelryck, B., Girault, J.P., Chottard, G., Valadon, P., Laoui, A. and Chottard, J.C.(1987) Inorg. Chem. 26, 787–795.
Dijt, F.J., Chottard, J.C., Girault, J.P., and Reedijk, J. (1989), Eur. J. Biochem., 179, 333–344.
Schwartz A., Marrot L. and Leng M., (1989) Biochemistry, 28, 7975–7979.
Schaaper, R.M., Kunkel, T.A., and Loeb, L.A. (1983) Proc. Nat. Acad. Sci. USA 80, 487–491.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Burnouf, D., Gauthier, C., Chottard, JC., Fuchs, R.P.P. (1991). Molecular Aspects of Repair and Mutagenesis of cis-Platinum-Induced Lesions. In: Howell, S.B. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0738-7_19
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0738-7_19
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0740-0
Online ISBN: 978-1-4899-0738-7
eBook Packages: Springer Book Archive