Signal Transduction Pathway Regulation of DDP Sensitivity
Signal transduction pathways play a central role in the regulation of cellular behavior, including growth and differentiation. It has been known for some time that the toxicity of many cancer chemotherapeutic agents is dependent on the activity of the biochemical pathway which they target. The hypothesis which we have been investigating is that growth factors, hormones and chemicals that activate signal transduction pathways can influence sensitivity to cisplatin (DDP). These studies have been conducted using ovarian carcinoma cell lines because they are representative of a type of tumor that is usually initially responsive to DDP chemotherapy in vivo.
KeywordsEpidermal Growth Factor Receptor Human Epidermal Growth Factor Receptor Human Epidermal Growth Factor Receptor Gene Ovarian Carcinoma Cell Line Human Ovarian Carcinoma Cell
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