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Synthesis and Antitumour Activity of Some Novel Platinum(II) Organoamides and Organometallics

  • Glen B. Deacon

Abstract

The success of cis-diamminedichloroplatinum(II) (Cisplatin) as an anticancer drug has led to intensive searches for analogous compounds,1–3 especially ones with reduced adverse side effects since Cisplatin is nephro-and neuro-toxic and causes pronounced nausea and vomiting.1–4 One second generation drug, diammine-1,1-cyclobutanedicarboxylatoplatinum(II) (Carboplatin) is less toxic and is now in clinical use.2–4 A further problem with Cisplatin is drug-resistance.5 This is unlikely to be alleviated by use of Carboplatin which shows cross-resistance with Cisplatin.4

Keywords

Antitumour Activity Human Colon Cancer Cell Line L1210 Leukaemia Nitrogen Donor Atom Growth Inhibition Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Glen B. Deacon
    • 1
  1. 1.Centre for the Synthesis and Evaluation of Advanced Chemicals and Materials, Chemistry DepartmentMonash UniversityClaytonAustralia

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