Synthesis and Antitumour Activity of Some Novel Platinum(II) Organoamides and Organometallics

  • Glen B. Deacon


The success of cis-diamminedichloroplatinum(II) (Cisplatin) as an anticancer drug has led to intensive searches for analogous compounds,1–3 especially ones with reduced adverse side effects since Cisplatin is nephro-and neuro-toxic and causes pronounced nausea and vomiting.1–4 One second generation drug, diammine-1,1-cyclobutanedicarboxylatoplatinum(II) (Carboplatin) is less toxic and is now in clinical use.2–4 A further problem with Cisplatin is drug-resistance.5 This is unlikely to be alleviated by use of Carboplatin which shows cross-resistance with Cisplatin.4


Antitumour Activity Human Colon Cancer Cell Line L1210 Leukaemia Nitrogen Donor Atom Growth Inhibition Property 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Glen B. Deacon
    • 1
  1. 1.Centre for the Synthesis and Evaluation of Advanced Chemicals and Materials, Chemistry DepartmentMonash UniversityClaytonAustralia

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