Developmental Approach to Prepare New Types of Antitumor Platinum Complexes with Dual Function

  • Yoshinori Kidani
  • Masahide Noji


cis-Platin, discovered by B. Rosenberg, et al. in 1969 is nowadays one of the best and widely used antitumor agents in cancer chemotherapy of testicular, ovarian, bladder cancers, as well as head and neck cancer. Various attempts have been made to prepare future generation antitumor Pt complexes, ameliorating severe toxicities. Carboplatin has been developed as the 2nd generation Pt complex of less nephrotoxic agent, but it still shows severe myelosuppression and cross-resistance.


Antitumor Activity Nitrogen Mustard Nephrotoxic Agent Amine Hydrochloride High Antitumor Activity 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Yoshinori Kidani
    • 1
  • Masahide Noji
    • 1
  1. 1.Nagoya City UniversityMizuho-ku, Nagoya 467Japan

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