Abstract
The function of the transplanted organ is influenced by three events, namely reperfusion injury, acute rejection and transplant vascular disease. The latter was previously called chronic rejection, and is now frequently referred to as transplant atherosclerosis (1).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M. L. Foegh, Chronic rejection–Graft arteriosclerosis, Transpl. Proc. 22: 119–122 (1990).
J. V. Conte, N. M. Katz, R. B. Wallace, M. L. Foegh, Long term lung preservation with the PAF antagonist BN 52021, Transplantation, in press.
P. C. Corcoran, Y. Wang, N. M. Katz, S. S. Rajan, A. R. Analouei, M. L. Foegh, R. B. Wallace, Platelet activating factor antagonist enhances lung preservation in canine model of single lung allotransplantation, J. Thor. Cardiovasc. urg., in press.
P. J. Jacobsson, B. Odlauder, K. A. Yamaoka, A. Rosen, H. E. Claesson, Biosynthesis and biological effects of leukotriene B4 in B-lymphocytes, Adv. Prostaglandins, Thromboxane, Leukotriene Res. 21B: 1005–1012 (1991).
S. E. Dahlen, C. N. Serhan, Lipoxins: Bioactive lipoxygenase interaction products, p. 235–276, in: “Lipoxygenases And Their Products,” Academic Press, New York (1991).
M. L. Foegh, Immune regulation by eicosanoids, Transpl. Proc. 20: 1158–1161 (1988).
M. L. Foegh, E. Chambers, B. S. Khirabadi, T. Nakanishi, P. W. Ramwell, Platelet-activating factor in organ transplant rejection, Adv. Prostaglandins Thromboxane Leukotriene Res. 19: 377–382 (1989).
M. Rola-Pleszczynski, B. Pignol, C. Pouliot, P. Braquet, Inhibition of human lymphocyte proliferation and interleukin-2 production by platelet activating factor (PAFacether): Reversal by a specific antagonist, BN 52021, Biochem. Biophvs. Res. Commun. l42 (3): 754–60 (1987).
M. I. McHugh, R. Wilkinson, R. W. Elliott et al., Immunosuppression with polyunsaturated fatty acids in renal transplantation, Transplantation 24: 263 (1972).
G. F. Schreiner, W. Flye, E. Brunt, et al., Essential fatty acid depletion of renal allografts and prevention of rejection, Science 240: 1032 (1988).
M. L. Foegh, B.S. Khirabadi, J. Rowles, P. Braquet, P. W. Ramwell, Prolongation of cardiac allograft survival with BN 52021, a specific antagonist of platelet-activating factor, Transplantation 42: 86 (1986).
J. R. Rowles, M. L. Foegh ML, The synergistic effect of cyclosporine and iloprost on survival of rat cardiac allografts, Transplantation 42: 94 (1986).
M. L. Foegh, B. S. Khirabadi, P. W. Ramwell, Improved rat cardiac allograft survival with nonsteroidal pharmacologic agents related to eicosanoids, Transpl. Proc. 19 (1): 1297–1300 (1987).
M. L. Foegh, B. S. Khirabadi, R. Shapiro, M. R. Alijani, M. H. Goldman, R. R. Lower, P. W. Ramwell, Monitoring of rat heart allograft rejection by urinary thromboxane, Transpl. Proc. 16: 1606 (1984).
M. Foegh, J. F. Winchester, M. Zmudka, G. B. Helfrich, C. Cooley, P. W. Ramwell, G. E. Schreiner, Urinary iTXB2 in renal allograft rejection, Lancet 2: 431 (1981).
L. K. Lim, M. R. Alijani, M. L. Foegh, Fine needle aspiration biopsy, serum B2-microglobulin, and urine thromboxane in renal allografts, Transpl. Proc. 21: 3583 (1989).
M. Kuwahara, J. Jacobsson, M. Kuwahara, E. Kagan, P. W. Ramwell, M. L. Foegh, Coronary artery ultrastructural changes in cardiac transplant atherosclerosis in the rabbit, Transplantation, in press.
M. L. Foegh, Chambers E, B. S. Khirabadi, T. Nakanishi, P. W. Ramwell, Platelet-activating factor in organ transplant rejection, Adv. Prostaglandin Thromboxane Leukotriene Res. 19: 377–382 (1989).
M. L. Foegh, B. S. Khirabadi, E. Chambers, S. Amamoo, P. W. Ramwell, Inhibition of coronary artery transplant atherosclerosis in rabbits with angiopeptin, an octapeptide, Atherosclerosis 78: 229–236 (1989).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Foegh, M. (1991). Lipid Mediators in Transplantation Reperfusion Injury, Acute Rejection and Accelerated Transplant Atherosclerosis. In: Bailey, J.M. (eds) Prostaglandins, Leukotrienes, Lipoxins, and PAF. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0727-1_36
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0727-1_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0729-5
Online ISBN: 978-1-4899-0727-1
eBook Packages: Springer Book Archive