Abstract
Our initial study of breast tumor prostaglandins concerned their relationship to the spread of the cancer to bone. This investigation, in which patient recruitment was started in 1974 and ended in 1978, was later extended to an examination of the relationship between tumor prostaglandins and patient survival. We found a highly significant inverse relationship (Bennett et al 1980) between the time to death and tumor PG-LM (prostaglandin-like material, so-called because the extracted prostaglandins were bioassayed against PGE2 on rat gastric fundus) (Bennett et al 1973).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Badwe, R. A., Gregory, W. M., Chaudary, M. A., Richards, M. A., Bentley, A. E., Rubens, R. D., and Fentiman, I., 1991, Timing of surgery during menstrual cycle and survival of premenopausal women with operable breast cancer. Lancet, 337: 1261.
Bennett, A., Jarosik, C., Sanger, G. J., and Wilson, D. E., 1980, Antagonism of prostanoid-induced contractions of rat gastric fundus muscle by SC-19220, sodium meclofenamate, indomethacin or trimethoquinol. Br. J. Pharmacol., 71: 169.
Bennett, A., Stamford, I. F., Berstock, D. A., Dische, F., Singh, L., and A’Hern, R. P., 1989, Breast cancer, prostaglandins and patient survival. Br. J. Cancer, 59: 268.
Bennett, A., Stamford, I. F., and Unger, W. G., 1973, Prostaglandin E2 and gastric acid secretion in man. J. Physiol., 229: 349.
Bennett, A., Berstock, D. A., Harris, M., Raja, B., Rowe, D. R., Stamford, I. F., and Wright, J. E., Prostaglandins and their relationship to malignant and benign human breast tumours. In: Advances in Prostaglandin and Thromboxane Research, Vol. 6, B. Samuelsson, PW Ramwell and R Paoletti, eds., Raven Press, New York, pp 595–600 (1980).
Korenman, S. G., and Dukes, B. A., 1970, Specific estrogen binding by the cytoplasm of human breast carcinoma. J. Clin. Endocrinol. Metab., 30: 639.
Lee, E., and Desu, M., 1972, A computer program for comparing K samples with right-censored data. Computer Prog. Biomed., 2: 315.
Malachi, T., Chaimoff, C. H., Feller, N., and Halbrecht, I., 1981, Prostaglandin E2 and cyclic AMP in tumor and plasma of breast cancer patients. J. Cancer Res. Clin. Oncol., 102: 71.
Rolland, P. H., Martin, P. M., Jacquemier, J., Rolland, A. M., and Toga, M. 1980, Prostaglandins in human breast cancer: evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cells. J. Natl. Cancer Inst., 64: 1061.
Unger, W. G., Stamford, I. F., and Bennett, A., 1971, Extraction of prostaglandins from human blood. Nature, 223: 336.
Van Dam, P. A., Vergoete, I. B., Laekeman, G. M., Keersmaekers, G. H., Uyttenbroeck, F. L., and Herman, A.G., 1989, Prognostic value of prostaglandin F2« concentrations in breast carcinoma. J. Clin. Pathol., 42: 1046.
Vergoete, I. B., Laekman, G. M., Keersmaekers, G. H., Uyttenbroeck, F. L., Vanderheyden, J. S., Albertyn, G. P., Haensch, C. F., DeRoy, G. J., and Herman, A. G., 1985, Prostaglandin F2« in benign and malignant breast tumours. Br. J. Cancer, 51: 827.
Watson, D. M. A., Kelly, R. W., and Miller, W. R., 1987, Prostaglandins and prognosis in human breast cancer. Br. J. Cancer, 56: 367.
Wilson, A. J., Baum, M., Bennett, A., Griffiths, K., Nicholson, R.I., and Stamford, I. F., 1980, Lymph node status, prostaglandins and oestrogen receptors are independent prognostic variables in human primary breast cancer. Clin. Oncol., 6: 379.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Bennett, A., Baum, M., Cooper, D., Stamford, I.F., Wilson, A.J. (1991). Tumor Prostaglandins and Estrogen Receptors: Prediction of Survival in Patients with Early Breast Cancer. In: Bailey, J.M. (eds) Prostaglandins, Leukotrienes, Lipoxins, and PAF. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0727-1_35
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0727-1_35
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0729-5
Online ISBN: 978-1-4899-0727-1
eBook Packages: Springer Book Archive