Modulation of Cytokine Gene Expression by LTB4 and PAF: Transcriptional and Post-Transcriptional Regulation

  • Marek Rola-Pleszczynski
  • Jana Stankova
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


In recent years, the potential for lipid mediators of inflammation, such as LTB4 and PAF, to modulate the production of cytokines has been demonstrated in several laboratories1–12. Lipid mediators and cytokines appear to play a role in various stages of inflammatory and immune responses, and may interact with each other to generate positive or negative feedback loops. Recent studies in our laboratories were aimed at elucidating the mechanisms through which LTB4 and PAF could modulate the production of interleukin (IL)1α, IL1β, IL6 and tumor necrosis factor α (TNF) by human monocytes and myeloid cell lines. Both transcriptional and post-transcriptional regulation of cytokine gene expression could be demonstrated.


Human Monocyte Lipid Mediator mRNA Accumulation Cytokine Gene Expression Tumor Necrosis Factor Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Marek Rola-Pleszczynski
    • 1
  • Jana Stankova
    • 1
  1. 1.Immunology Division, Department of Pediatrics Faculty of MedicineUniversity of SherbrookeSherbrookeCanada

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